Improving prediction accuracy of drug activities by utilising unlabelled instances with feature selection
DOI: 10.1504/IJCBDD.2008.018706 | Guo-Zheng Li, Jack Y. Yang, Wen-Cong Lu, Dan Li, Mary Qu Yang | Molecular activities can be predicted by Quantitative Structure Activity Relationship (QSAR). Because of the high cost of experiments, the number of drug molecules with known activity is much less than that of unknown, to predict molecular ... | 1 - 13 |
Prediction of lipid-interacting amino acid residues from sequence features
DOI: 10.1504/IJCBDD.2008.018706 | Liangjiang Wang, Stephanie J. Irausquin, Jack Y. Yang | Proteins and lipids are integral components of cell membranes, and play important roles in cell signalling. Alterations of normal protein-lipid recognition may cause various diseases. However, molecular mechanisms underlying protein-lipid r... | 14 - 25 |
A comparison of algorithms for a complete backtranslation of oligopeptides
DOI: 10.1504/IJCBDD.2008.018706 | Mohieddine Missaoui, David R.C. Hill, Pierre Peyret | In the context of new metabolic pathways discovery, a full backtranslation of oligopeptides can be a promising approach. When studying complex environments where the composing microorganisms are unknown, it is also preferable to have all th... | 26 - 38 |
Detection and prediction of alternative splicing in Arabidopsis thaliana
DOI: 10.1504/IJCBDD.2008.018706 | M. Park, D.L. Falcone, K.M. Daniels | Alternative splicing is an important process for increasing the diversity arising from a single gene. Presently, most studies aimed at detecting alternatively spliced genes use Expressed Sequence Tags (ESTs). However, the EST studies based ... | 39 - 58 |
Inferring Transcription Factor interactions using a novel HV-SVM classifier
DOI: 10.1504/IJCBDD.2008.018706 | Xiao-Li Li, Jun-Xiang Lee, Bharadwaj Veeravalli, See-Kiong Ng | Interactions between Transcription Factors (TFs) are necessary for deciphering the complex mechanisms of transcription regulation in eukaryotes. We proposed a novel HV-kernel based SVM classifier to classify TF-TF pairs based on their prote... | 59 - 73 |
Parsimony accelerated Maximum Likelihood searches
DOI: 10.1504/IJCBDD.2008.018706 | Kenneth Sundberg, Timothy O|Connor, Hyrum Carroll, Mark Clement, Quinn Snell | Phylogenetic search is a key tool used in a variety of biological research endeavours. However, this search problem is known to be computationally difficult, due to the astronomically large search space, making the use of heuristic methods ... | 74 - 87 |
Approximate strip exchanging
DOI: 10.1504/IJCBDD.2008.018706 | Swapnoneel Roy, Ashok Kumar Thakur | Genome rearrangements have been modelled by a variety of primitives such as reversals, transpositions, block moves and block interchanges. We consider such a genome rearrangement primitive Strip Exchanges. Given a permutation, the challenge... | 88 - 101 |
