Scientific Review: A new insight on predicting tumour malignancies using synergistic computational intelligence and bioinformatics approaches
DOI: 10.1504/IJCIBSB.2009.024040 | Jack Y. Yang, Andrzej Niemierko, Zuojie Luo, Mary Qu Yang | Recently, the National Human Genome Research Institute and National Cancer Institute, both part of NIH, US Department of Health and Human Services, have launched The Cancer Genome Atlas (TCGA). Based on the mission of TCGA, we have proposed... | 4 - 14 |
Computational intelligence for genetic association study in complex diseases: review of theory and applications
DOI: 10.1504/IJCIBSB.2009.024040 | Arpad Kelemen, Athanasios V. Vasilakos, Yulan Liang | Comprehensive evaluation of common genetic variations through association of SNP structure with common complex disease in the genome-wide scale is currently a hot area in human genome research thanks for the recent development of the Human ... | 15 - 31 |
Design of an RNA structural motif database
DOI: 10.1504/IJCIBSB.2009.024040 | Dongrong Wen, Jason T.L. Wang | In this paper we present the design and implementation of an RNA structural motif database, called RmotifDB. The structural motifs stored in RmotifDB come from three sources: collected manually from the biomedical literature; submitted by ... | 32 - 41 |
Efficient non-coding RNA gene searches through classical and evolutionary methods
DOI: 10.1504/IJCIBSB.2009.024040 | Scott F. Smith | Successful non-coding RNA gene searching requires examination of long-range intramolecular base pairing possibilities. This results in search algorithms with extremely long run times such that large-scale use of the algorithms often becomes... | 42 - 58 |
Hybrid SVM-ANFIS for protein subcellular location prediction
DOI: 10.1504/IJCIBSB.2009.024040 | Bo Jin, Yuchun Tang, Yan-Qing Zhang | Predicting protein subcellular locations may help us understand protein functions and analyse protein interactions with other molecules. Many machine learning and computational techniques have been used to predict protein subcellular locati... | 59 - 73 |
Improved biomedical document retrieval system with PubMed term statistics and expansions
DOI: 10.1504/IJCIBSB.2009.024040 | Huian Li, Jake Yue Chen | Large biomedical abstract databases such as MEDLINE enable users to search for large bodies of biomedical knowledge quickly. In this study, we describe a new framework to improve the performance of MEDLINE document retrieval. We first analy... | 74 - 85 |
Time lagged recurrent neural network for temporal gene expression classification
DOI: 10.1504/IJCIBSB.2009.024040 | Yulan Liang, Arpad Kelemen | Heterogeneous gene expressions provide insight into the biological role of gene interaction with the environment, disease development and drug effect at the molecular level. We propose Time Lagged Recurrent Neural Network with trajectory le... | 86 - 99 |
Orthogonal projection weights in dimension reduction based on Partial Least Squares
DOI: 10.1504/IJCIBSB.2009.024040 | Xue-Qiang Zeng, Guo-Zheng Li, Mary Qu Yang, Geng-Feng Wu, Jack Y. Yang | Dimension reduction is important during the analysis of gene expression microarray data, because the high dimensionality in the data set hurts the generalisation performance of classifiers. Partial Least Squares Based Dimension Reduction (P... | 100 - 115 |
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