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International Journal of Nano and Biomaterials (3 papers in press)
Finite Element Analysis of Synthetic and Natural Polymer Blends made by 3D Printing by Gajanan Thokal, Chandrakant Patil Abstract: The use of synthetic and natural polymer blends can increase the range of structures and properties of 3D printing (3DP) parts. This study investigates the blends specimen prepared using polyamide (PA12) and nanocrystalline cellulose (NCC) with formic acid solution. The various composition mixtures were prepared. The processing conditions and their influence on mechanical properties of specimens manufactured were evaluated. The microstructural behaviour of the PA12/NCC blends material developed using scanning electron microscope. The mechanical properties are evaluated, as well as its biomechanical performance was observed. The static tests were performed to evaluate the compressive stress as well as youngs modulus. The porosity measurements were done using gas porosimeter to assess the strength. The finite element analysis was done to simulate the results obtained by experimentations. It was found that PA12/NCC blends had bone matching properties of goat. The overall performance of the PA12/NCC blend conforms that this can be an alternate material for implant applications. Keywords: Polyamide12 (PA12); Nanocrystalline Cellulose (NCC); Three Dimensional Printing (3DP); Stress Shielding; Formic Acid.
FORMULATION, CHARACTERIZATION AND COMPARISON OF DIFFERENT RALOXIFENE HYDROCHLORIDE LOADED LIPID-POLYMER HYBRID NANOPARTICLES by Syed Mahmood, Tan Cheh Phey, Lee Seow Kheng, Kee Poh Chen, Uttam Kumar Mandal Abstract: This study aims to formulate raloxifene loaded lipidpolymeric hybrid nanoparticles (LPHNPs) and the comparison of their properties. Three LPHNPs, each with phosphatidylcholine- lipid (PCL) as bilayer-forming-membrane with three different polymers like sodium alginate, chitosan and poly(lactic-co-glycolic-acid) were prepared by nanoprecipitation, solvent injection and emulsion solvent evaporation, respectively. Results showed that the prepared formulations were spherical-shaped with a heterogeneity. Surface morphology was viewed using a scanning electron microscope (SEM).A high entrapment efficiency (>70%) with a sustained and pH dependent drug release profile for 24 h was observed and evaluated using mathematical kinetic modelling. Fourier transform infrared spectroscopy was used to confirm successful entrapment of raloxifene after evaluating the interaction and compatibility of the excipients used. Whereas, differential scanning calorimetry and x-ray diffraction revealed the transformation of raloxifene into an amorphous form. In conclusion, these hybrid nanoparticles provide a promising approach for oral delivery of raloxifene. Keywords: Raloxifene; lipid-polymeric hybrid nanoparticle; release study; stability test; pharmacokinetic release modelling.
Synergistic effect of DNA interfacing on Carbon nanotube field effect transistor devices by Richa Rastogi, B.D. Pant, Lalit M. Bharadwaj Abstract: Successful integration of carbon nanotubes (CNTs) in electronic devices and sensors requires controlled deposition at well defined locations and appropriate electrical contacts to metal electrodes/leads. Controlled self-assembly of CNTs can be achieved by interfacing them with biological molecule like DNA using its self-recognition property. However, these biointerfaces can produce undesirable changes in their device characteristics. Herein, we report an extensive study of effect of DNA interfacing on device characteristics of carbon nanotube field effect transistors and explored its synergistic effects as self-assembling element in future nanodevices. Single walled carbon nanotubes (SWNTs) are interfaced with DNA (via both covalent and noncovalent methodology) and electronic transport properties of corresponding field effect transistor devices have been studied in order to have an insight into changes in the electrical properties of SWNTs after interfacing. It was concluded that covalently linked DNA is not appropriate for self-assembly of carbon nanotubes in future nanodevices as it ruins its electrical characteristics. Keywords: Carbon Nanotubes; DNA; Field effect transistor; Transconductance; Schottky barrier.