These articles have been peer-reviewed and accepted for publication but are pending final changes, are not yet published and may not appear here in their final order of publication until they are assigned to issues. Therefore, the content conforms to our standards but the presentation (e.g. typesetting and proof-reading) is not necessarily up to the Inderscience standard. Additionally, titles, authors, abstracts and keywords may change before publication. Articles will not be published until the final proofs are validated by their authors.
Forthcoming articles must be purchased for the purposes of research, teaching and private study only. These articles can be cited using the expression "in press". For example: Smith, J. (in press). Article Title. Journal Title.
Articles marked with this shopping trolley icon are available for purchase - click on the icon to send an email request to purchase.
International Journal of Immunological Studies (3 papers in press)
REVIEW ARTICLE - MANAGEMENT OF RHEUMATOID ARTHRITIS by MARIA AZIZ, Kush Yadav Abstract: The review article covers every aspect of treatment modalities of Rheumatoid Arthritis (RA) patients .The importance of Reverse pyramid approach,with early aggressive treatment has been highlighted with due consideration to Adjuvant therapies .Treatment of Comorbid conditions has also been considered.Targetized Goals of treatment have been stressed for Rheumatologist while designing the management plan for RA patients. Keywords: Rheumatoid Arthritis; Management; DMARDs; Reverse Pyramid approach rn.
Changes in Activation Status of Dendritic Cells and Cytokine Profile in Type 2 Diabetes Mellitus with Good vs Poor Glycemic Control by Jarupa Soongsathitanon, Apiradee Sriwijitkamol, Visith Thongboonkerd Abstract: Uncontrolled hyperglycemia gives rise to pathological lesion of blood vessel in diabetes mellitus (DM). Dendritic cells were evidenced in atherosclerotic plaque and involved in the pathogenesis of atherosclerosis in diabetes. This study investigated differences in the phenotype of monocyte-derived dendritic cells in patients with different level of glycemic control. Expression of activation markers, CD80 and CD86, on dendritic cells was compared between type 2 DM patients with good glycemic control (HbA1c ≤ 7), poor glycemic control (HbA1c > 9), and non-diabetic subjects. CD80 expression was significantly increased in patients with poor glycemic control in comparison to good glycemic control and healthy subjects. CD86 expression was higher in diabetic patients, with either good or poor glycemic control. Cytokine assay showed higher levels of pro-inflammatory cytokines TNF-α, IL-6, IL-1β, IL-12, IFN-γ in diabetic patients. Monocyte chemoattractant protein-1, a chemokine recruiting inflammatory cells into atherosclerotic lesion, was increased in diabetic patients, with higher expression of its receptor, CCR2, in poor control group. This study demonstrated inflammatory state in type 2 DM and activated dendritic cells in poorly controlled diabetes. This may lead to vascular complications in diabetic patients. Keywords: Glycemic control; dendritic cell; atherosclerosis; HbA1c; MCP-1; diabetes mellitus.
Investigation of the cellular and soluble markers of inflammation for the assessment of cardiovascular risk in patients with acute coronary syndrome in Bangladesh by Talita Zahin Choudhury, Mohammad Kamruzzaman, Laila Noor Islam Abstract: Acute coronary syndrome (ACS), one of the leading causes of mortality in Bangladesh, occurs when a plaque in the coronary artery suddenly ruptures and obstructs the flow of blood to the heart causing myocardial tissue necrosis. In this study, a total of 140 participants were enrolled including 70 ACS patients and 70 non-ACS controls. The total and differential WBC counts, myeloperoxidase (MPO) activity, ischemia-modified albumin (IMA), interleukin-6 (IL-6) and complement functions were investigated and the values were compared between the study groups. We found the total WBC count, neutrophil to lymphocyte ratio (NLR), plasma MPO activity, serum IMA, and IL-6 levels were significantly higher in the ACS patients while the complement-mediated bactericidal activity was significantly lower. The results on NLR, MPO activity, and IL-6 levels demonstrate activation of cellular and soluble inflammatory mediators in ACS, which may be potential diagnostic biomarkers. Keywords: ACS; WBC counts; neutrophil to lymphocyte ratio (NLR); oxidative stress; MPO activity; markers of inflammation; IL-6; ishcaemia-modified albumin; complement function; diagnostic biomarkers; Bangladesh. DOI: 10.1504/IJIS.2018.10016181