Forthcoming and Online First Articles

International Journal of Computational Biology and Drug Design

International Journal of Computational Biology and Drug Design (IJCBDD)

Forthcoming articles have been peer-reviewed and accepted for publication but are pending final changes, are not yet published and may not appear here in their final order of publication until they are assigned to issues. Therefore, the content conforms to our standards but the presentation (e.g. typesetting and proof-reading) is not necessarily up to the Inderscience standard. Additionally, titles, authors, abstracts and keywords may change before publication. Articles will not be published until the final proofs are validated by their authors.

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International Journal of Computational Biology and Drug Design (2 papers in press)

Regular Issues

  • Importance of safety maintenance of the survived with recent former infection experience during a pandemic syndrome episode: A Study by Difference Equation Approach   Order a copy of this article
    by Subhasis Bhattacharya, Suman Paul, Sudip Mukherjee 
    Abstract: During the outbreak of a highly infectious disease conceded by a virus, handling of healthcare catastrophe is the most momentous part. Any type of known or unknown relaxation may generate enormous loss in terms of population. Present study consider the concern that survived one who has some fresh former infection history can be fingered with appropriate care throughout the syndrome period otherwise a huge harm can be advent by the state. The study follow difference equation modelling considering two aspects where the survived with former infection history handled with care and not reckoned as a part of sustained population and the other is they encompassed with the general population category. The study considers an example of a hypothetical state with some give infection rate, death rate and quarantine rate. By using R- programme language the study observes that proper care for such group of population is very significant to reduce the situation like human loss.
    Keywords: Infectious disease; SARS-CoV-2; 2019-nCov; Difference Equation; Survived from the infected; Quarantine rate; Death Rate.

  • Potential of the Flavonoid Compounds of Ageratum Conyzoides as Candidates for the Treatment of Foot-Mouth Diseases (FMD) in Livestock Animals: a Bioinformatics Approach   Order a copy of this article
    by Endik E.D.N. Nugroho, Ahmad Misbakhus Sururi, Reza R.A. Ardiansyah, Dwi D.A.R. Rahayu, Roisatul Ainiyah, Amang Fathurrohman, Zainul Ahwan, M. Dayat, Mulyono Wibisono, Fatit Rahmar Aji, Kasiman Kasiman 
    Abstract: Livestock ecology and economy are threatened by foot-and-mouth disease (FMD) caused by FMD-virus. Especially with natural herbal compounds, this difficulty remains. Overcoming this issue requires the discovery of herbal therapeutic ingredients, especially flavonoids. An herbaceous plant called Ageratum conyzoides may solve this problem. This work examines the in silico suppression of RdRp and 3Cpro FMDV by A. conyzoides flavonoid compounds as FMD antivirals. This study used precocene I, II, 5-methoxynobiletin, lycopsamine, sinensetin, eupalestin, quercetin, kaempferol, 5,6,7,8,3',5'-hexamethoxyflavone, and isoflavone glycosides. Potential compounds were then assessed for Lipinski druglikeness, ADME, and toxicity prediction. The results showed that six compounds could synergistically inhibit RdRp and 3Cpro, with binding values -6.9 to -7.5 kcal/mol lower than ribavirin, the control drug. Lipinski's druglikeness analysis implies oral drug potential for the six substances. As an FMD-antiviral candidate, ADMET (Absorption, Distribution, Metabolism, and Excretion) analysis is also positive. Further research is needed to determine the anti-FMD potential.
    Keywords: Ageratum conyzoides; Foot and Mouth Disease; Virus; inhibitor.
    DOI: 10.1504/IJCBDD.2024.10062280