Title: A hypothesis for the elimination of necrotic cell components: the elimination of necrotic cell components and the development of autoimmune diseases

Authors: Borros M. Arneth

Addresses: Institute of Clinical Chemistry and Laboratory Medicine, Carl Gustav Carus University Hospital, Technische Universität Dresden (TU-Dresden), Fetscher Str. 74, 01307 Dresden, Germany

Abstract: Autoimmune diseases are known to be associated with autoantibodies against intracellular structures. Here, we describe the hypothesis that these diseases could develop as a result of the extensive production and release of intracellular substances into the serum. Autoimmune diseases may also develop as a result of defective elimination of multiple intracellular components and of proteins. Elimination defects may occur in any of several pathways, including those affecting apoptosis, cellular degradation (e.g., by macrophages), and soluble enzymes.

Keywords: autoimmune diseases; auto-immunisation; elimination; necrosis; apoptosis; necrotic cell components; cellular degradation; macrophages; soluble enzymes.

DOI: 10.1504/IJIS.2012.051234

International Journal of Immunological Studies, 2012 Vol.1 No.4, pp.329 - 335

Published online: 30 Aug 2014 *

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