A hypothesis for the elimination of necrotic cell components: the elimination of necrotic cell components and the development of autoimmune diseases
by Borros M. Arneth
International Journal of Immunological Studies (IJIS), Vol. 1, No. 4, 2012

Abstract: Autoimmune diseases are known to be associated with autoantibodies against intracellular structures. Here, we describe the hypothesis that these diseases could develop as a result of the extensive production and release of intracellular substances into the serum. Autoimmune diseases may also develop as a result of defective elimination of multiple intracellular components and of proteins. Elimination defects may occur in any of several pathways, including those affecting apoptosis, cellular degradation (e.g., by macrophages), and soluble enzymes.

Online publication date: Sat, 30-Aug-2014

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