Forthcoming articles


International Journal of Immunological Studies


These articles have been peer-reviewed and accepted for publication in IJIS, but are pending final changes, are not yet published and may not appear here in their final order of publication until they are assigned to issues. Therefore, the content conforms to our standards but the presentation (e.g. typesetting and proof-reading) is not necessarily up to the Inderscience standard. Additionally, titles, authors, abstracts and keywords may change before publication. Articles will not be published until the final proofs are validated by their authors.


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International Journal of Immunological Studies (2 papers in press)


Regular Issues


    by MARIA AZIZ, Kush Yadav 
    Abstract: The review article covers every aspect of treatment modalities of Rheumatoid Arthritis (RA) patients .The importance of Reverse pyramid approach,with early aggressive treatment has been highlighted with due consideration to Adjuvant therapies .Treatment of Comorbid conditions has also been considered.Targetized Goals of treatment have been stressed for Rheumatologist while designing the management plan for RA patients.
    Keywords: Rheumatoid Arthritis; Management; DMARDs; Reverse Pyramid approach rn.

  • Changes in Activation Status of Dendritic Cells and Cytokine Profile in Type 2 Diabetes Mellitus with Good vs Poor Glycemic Control   Order a copy of this article
    by Jarupa Soongsathitanon, Apiradee Sriwijitkamol, Visith Thongboonkerd 
    Abstract: Uncontrolled hyperglycemia gives rise to pathological lesion of blood vessel in diabetes mellitus (DM). Dendritic cells were evidenced in atherosclerotic plaque and involved in the pathogenesis of atherosclerosis in diabetes. This study investigated differences in the phenotype of monocyte-derived dendritic cells in patients with different level of glycemic control. Expression of activation markers, CD80 and CD86, on dendritic cells was compared between type 2 DM patients with good glycemic control (HbA1c ≤ 7), poor glycemic control (HbA1c > 9), and non-diabetic subjects. CD80 expression was significantly increased in patients with poor glycemic control in comparison to good glycemic control and healthy subjects. CD86 expression was higher in diabetic patients, with either good or poor glycemic control. Cytokine assay showed higher levels of pro-inflammatory cytokines TNF-α, IL-6, IL-1β, IL-12, IFN-γ in diabetic patients. Monocyte chemoattractant protein-1, a chemokine recruiting inflammatory cells into atherosclerotic lesion, was increased in diabetic patients, with higher expression of its receptor, CCR2, in poor control group. This study demonstrated inflammatory state in type 2 DM and activated dendritic cells in poorly controlled diabetes. This may lead to vascular complications in diabetic patients.
    Keywords: Glycemic control; dendritic cell; atherosclerosis; HbA1c; MCP-1; diabetes mellitus.