Triiodophenyl acrylate-based microbeads find important use in the medical field Online publication date: Fri, 28-Nov-2014
by Catalin Zaharia; Teodora Zecheru; Lucian Lerescu; Mihaela-Ramona Tudora; Florin Miculescu; Corneliu Cincu
International Journal of Nano and Biomaterials (IJNBM), Vol. 3, No. 4, 2011
Abstract: Preparation of polymeric micro- and nanoparticles has significantly become an effective approach for achieving efficient drug targeting to tumour tissues. A promising solution could be the use of a radio-opaque polymeric system carrying iodine groups. In this context, radio-opaque polymeric microparticles based on methyl methacrylate (MMA) and an 2,4,6-triiodophenyl acrylate (TIPA) were synthesised by suspension and emulsion polymerisation techniques. Various compositions of p(MMA-co-TIPA) were physico-chemically and biologically characterised through FTIR-ATR, SEM, EDX, in vitro biocompatibility and X-ray measurements. These copolymers exhibit good in vitro cell compatibility together with good X-ray visibility so they are good candidates for tumour detection and imaging.
Online publication date: Fri, 28-Nov-2014
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