Title: Triiodophenyl acrylate-based microbeads find important use in the medical field

Authors: Catalin Zaharia; Teodora Zecheru; Lucian Lerescu; Mihaela-Ramona Tudora; Florin Miculescu; Corneliu Cincu

Addresses: Advanced Polymer Materials Group, University Politehnica of Bucharest, Calea Victoriei 149, 010072 Bucharest, Romania. ' Scientific Research Centre for CBRN Defense and Ecology, 225 Sos. Olteni?ei, Sector 4, 041309 Bucharest, Romania. ' National Institute for Research-Development of Microbiology and Immunology, Cantacuzino', Splaiul Independentei 103, Sector 5, 1-525, 050096, Bucharest, Romania. ' Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Calea Victoriei 149, 010072 Bucharest, Romania. ' Materials Science and Engineering Faculty, University Politehnica of Bucharest, Splaiul Independentei 313, Bucharest, Sector 6, Romania. ' Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Calea Victoriei 149, 010072 Bucharest, Romania

Abstract: Preparation of polymeric micro- and nanoparticles has significantly become an effective approach for achieving efficient drug targeting to tumour tissues. A promising solution could be the use of a radio-opaque polymeric system carrying iodine groups. In this context, radio-opaque polymeric microparticles based on methyl methacrylate (MMA) and an 2,4,6-triiodophenyl acrylate (TIPA) were synthesised by suspension and emulsion polymerisation techniques. Various compositions of p(MMA-co-TIPA) were physico-chemically and biologically characterised through FTIR-ATR, SEM, EDX, in vitro biocompatibility and X-ray measurements. These copolymers exhibit good in vitro cell compatibility together with good X-ray visibility so they are good candidates for tumour detection and imaging.

Keywords: iodine-based polymers; EPR effect; microbeads; radio-opacity; polymeric nanoparticles; drug targeting; tumour tissues; methyl methacrylate; MMA; triiodophenyl acrylate; TIPA; suspension polymerisation; emulsion polymerisation; biocompatibility; tumour detection; tumour imaging; copolymers; cancer; X-ray visibility.

DOI: 10.1504/IJNBM.2011.045888

International Journal of Nano and Biomaterials, 2011 Vol.3 No.4, pp.302 - 315

Available online: 14 Mar 2012 *

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