Forthcoming and Online First Articles

International Journal of Experimental and Computational Biomechanics

International Journal of Experimental and Computational Biomechanics (IJECB)

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International Journal of Experimental and Computational Biomechanics (2 papers in press)

Regular Issues

  • Evaluating effect of amputees physical parameters on pressure at lower-limb prosthetic socket   Order a copy of this article
    by Chitresh Nayak, Deepak Unune, Amit Singh, Himanshu Choudhary 
    Abstract: Intrasocket pressures can cause the tissue trauma or discomfort to amputees wearing the prosthetic devices. This paper presents a methodology for evaluating the role of amputees physical parameters viz. height, weight, and stump length on pressure generated at the prosthetic limb/socket interface using regression technique. An experimental setup has beed developed for force investigation of the lower-limb socket using the FlexiForce sensor. The intrasocket pressure values at lateral tibia, gastrocnemius, patella tendon bearing, kick point, medial tibia, medial gastrocnemius, popliteal depression, and lateral gastrocnemius on the transtibial residual limb have been collected for three different conditions viz. walking, full load and half load for ten patients. Mathematical models for pressure at three loading conditions have been developed using regression analysis using which the effective pressure at considered specific regions can be correlated with physical parameters. The models suggested that the weight of amputee is a strong predictor of pressure at the socket. The developed methodology will assist the amputee-specific socket design ensuring comfortable socket fitting.
    Keywords: Stump-socket interface; pressure measurement; regression analysis; socket fitting.

  • A Model for the Roles of Actin and Myosin in Adjustable Preload Tension and Acute Length Adaption   Order a copy of this article
    by Omid Komari, Adam Klausner, Paul Ratz, John Speich 
    Abstract: Muscle mechanical behaviour potentially plays an important role in some of the most common bladder disorders. These include overactive bladder, which can involve involuntary contractions during bladder filling, and impaired contractility or underactive bladder, which may involve weak or incomplete contractions during voiding. Actin-myosin cross-bridges in detrusor smooth muscle (DSM) are responsible for contracting and emptying the bladder. The total tension produced by the muscle is the sum of its preload and active tensions. Studies suggest that actin-myosin cross-links are involved in adjustable preload stiffness (APS), which is characterized by a preload tension curve that can be shifted along the length axis as a function of strain history and activation history. DSM also exhibits length adaptation in which the active tension curve can exhibit a similar shift. Actin-myosin cross-bridges are also responsible for myogenic contractions in response to quick stretch of DSM strips and spontaneous rhythmic contractions (SRC) that may occur during bladder filling. Studies show that SRC may participate in the mechanical regulation of both APS and length adaptation. However, the mechanical mechanisms of these interrelated functions are unknown. This study focused on developing a conceptual model with actin-myosin cross-bridges and cross-links that produce the coupled mechanical behaviours of APS, SRC, and length adaptation in DSM.
    Keywords: Biomechanics; Tissue Biomechanics; Biomechanical Models; Detrusor Smooth Muscle; Urodynamic; Length-tension curve; Adjustable preload tension; Actin-Myosin; Spontaneous Rhythmic Contractions.
    DOI: 10.1504/IJECB.2023.10055952