Forthcoming and Online First Articles

International Journal of Biotechnology

International Journal of Biotechnology (IJBT)

Forthcoming articles have been peer-reviewed and accepted for publication but are pending final changes, are not yet published and may not appear here in their final order of publication until they are assigned to issues. Therefore, the content conforms to our standards but the presentation (e.g. typesetting and proof-reading) is not necessarily up to the Inderscience standard. Additionally, titles, authors, abstracts and keywords may change before publication. Articles will not be published until the final proofs are validated by their authors.

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International Journal of Biotechnology (4 papers in press)

Regular Issues

  • The yield and price effects of growing genetically modified corn: evidence from the US corn belt   Order a copy of this article
    by Prince Fosu 
    Abstract: This study investigates the impact of GM corn adoption on yield and price for the US corn belt from 2014 to 2020. In addition, the study investigates the interaction effects of GM corn and yield on price and analyses the impact of both temporary and permanent shocks of growing GM corn on yield and price. The results indicated that the GM corn adoption had a positive impact on yield and a negative and statistically significant impact on price. Also, the interaction effect of GM corn and yield impacted positively on the price, suggesting that the adoption of GM corn should increase the negative effect of yield on price. The temporary shock of growing GM corn positively impacted yield and price while the permanent shock negatively affected yield and price. The study suggested that the adoption of GM corn has implications for improving producer and consumer welfare and global food security.
    Keywords: genetically modified corn; price; yield; USA; corn belt.
    DOI: 10.1504/IJBT.2022.10049247
     
  • Perceptions of types, influences, and how select Central European entrepreneurship ecosystems developed in the biopharmaceutical sector   Order a copy of this article
    by David R. Williams 
    Abstract: The present paper seeks to explore factors related to the types, influences, reasons for influences, and how entrepreneurship ecosystems developed in the biopharmaceutical sector in select regions of Central Europe. It is motivated by specific gaps in the literature related to entrepreneurial ecosystems. Findings from a survey of multiple actors’ perceptions in these areas are presented. Findings show that most ecosystems reside in areas with multiple innovative industries, that this has a slight positive influence on the development of this sector, and that over time these entrepreneurial ecosystems are becoming more directed as opposed to growing spontaneously.
    Keywords: entrepreneurship ecosystems; development; Central Europe.
    DOI: 10.1504/IJBT.2022.10051121
     
  • The CHO cell line as a potentially safer host for cetuximab therapeutic antibody production than the Sp2/0 cell line   Order a copy of this article
    by Edyta E. Bartusik-Czubek, Bartłomiej M. Czubek, Paulina E. Toboła, Karolina M. Lonkwic, Piotr P. Miłek, Olga H. Grzyb, Julita A. Balcerek, Tadeusz Pietrucha, Sławomir Jaros 
    Abstract: The host cell line has an influence on the quality of recombinant protein. In case of monoclonal antibodies, the most frequently chosen are hamster and mouse-derived cell lines. However, glycosylation profile of the mAb generated by these cell lines is expected to be different. In this study, we used the cetuximab protein obtained from Sp2/0 and CHO cell lines. The content of fucosylated and nonfucosylated glycoforms, as well as structures containing N-glycolylneuraminic acid, N-acetylneuraminic acid and Gal-Gal structures were analysed. Our results confirm literature data regarding higher level of fucosylated glycoforms and a higher level of N-acetylneuraminic acid in CHO- than Sp2/0 derived cetuximab. We also confirm lack of Gal-Gal structures in CHO derived antibody. Moreover, we have demonstrated the Sp2/0- and CHO-derived IgG can have comparable nonfucosylated glycoforms content. This is a significant finding since nonfucosylated species are the triggers of the biological activities of many antibodies.
    Keywords: antibodies; antibody production; bioanalysis; biosimilars; biotechnology; cetuximab; cell lines; Chinese hamster ovary cell line; glycoproteins; glycosylation.
    DOI: 10.1504/IJBT.2023.10056057
     
  • Bacteriological profile of blood culture isolation and their antibiotic susceptibility pattern in BIMR Hospital, Gwalior, India   Order a copy of this article
    by Santosh Kumar, Pranshu Sharma, Anju Goyal, Sujeet Mritunjay, Nem Kumar Jain, Varsha Chauhan, Akshay Singh Sengar, Moti Lal 
    Abstract: Blood stream infections can result in sepsis, a condition that can be fatal. Blood culture is the most effective way to diagnosis of sepsis. Multi-drug resistant (MDR) organisms have a higher probability to raise mortality risk of patients. Blood sample was collected and transferred into a bottle of blood culture and incubated for 5 days. The most typical organism isolated was Stenotrophonomas maltophilia (39.65%) which was followed by Staphylococcus aureus (20%) in terms of frequency. The most frequent isolate, Stenotrophomonas maltophilia, was 100% sensitive to Chloramphenicol, 95.65% to Trimethoprim-sulfamethoxazole and 86.95% sensitive to Levofloxacin. Daptomycin, vancomycin and linezolid showed 100% sensitivity against all identified gram positive bacilli (GPC). According to the current study, the most prevalent isolates from blood cultures were stenotrophomonas maltophilia and staphylococcus aureus, which is predominant organisms causing septicemia. Stenotrophomonas maltophilia, had greater susceptibility to chloramphenicol, Trimethoprim-sulfamethoxazole and levofloxacin. Staphylococcus aureus, showed higher sensitivity to daptomycin, vancomycin, linezolid.
    Keywords: multi-drug resistant; MDR; septicaemia; blood culture; blood-stream infections; stenotrophomonas maltophilia; antibiotic susceptibility.