International Journal of Biomedical Nanoscience and Nanotechnology
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International Journal of Biomedical Nanoscience and Nanotechnology (2 papers in press)
Recent advances in chemical functionalisation of graphene and sensing applications by Geoffrey Ijeomah, Fahmi Samsuri, Mohamad Adzhar Md Zawawi, Felix Obite Abstract: Graphene, a one-atom-thick, sp2-hybridised allotrope of carbon, has attracted massive interest owing to its outstanding electrical, mechanical, thermal and optical properties. The material of graphene is remarkably stable, with a huge potential for developing various types of sensor, including biomedical sensing where enhanced specificity, sensitivity, label-free nature and cost effectiveness for rapid point-of-care detection of diseases are paramount. This is due to the simplicity with which its electronic properties can be modified since each atom in the structure directly interacts with the sensing environment. These unique characteristics can be exploited for several kinds of sensing application, such as electrochemical and electrical sensors as well as optical sensors. While pristine graphene is desirable for applications that require high electrical conductivity, many other applications require functionalised graphene for optimal performance. Therefore, the functionalisation of graphene is a significant step towards tuning its structure for various sensing applications. In this review, we report recent technological progress in the chemical functionalisation of graphene and its sensing applications. Keywords: graphene; sensors; biosensors; functionalisation; point-of-care detection.
Ameliorative effects of selenium nanoparticles on letrozole-induced polycystic ovarian syndrome in adult rats by Maisra Azhar Butt, Asad Ullah, Mubin Mustafa Kiyani, Sarwat Jahan Abstract: Selenium (Se) is an essential trace element playing vital role in the physiological processes. It was ignored as a therapeutic agent in the past, but in 1950s it was revealed that it must be obtained from diet as it cannot be produced by organisms. The present study was designed to investigate the anti-androgenic and metabolic effects of selenium nanoparticles (SeNPs) on letrozole-induced PCOS using female rats. All rats were administered orally with letrozole (1 mg/kg) in CMC (0.5%) for 36 days. Rats were provided with metformin (2 mg/kg), Se-I (250 mg/kg), Se-II (500 mg/kg), SeNPs-I (50 mg/kg) and SeNPs-II (100 mg/kg) for 15 days. On the 37th day animals were sacrificed and biochemical tests, antioxidants and histopathological analysis were performed. The results of the current study depict the anti-androgenic potential of Se and SeNP for the treatment of PCOS that can be a new drug in the management of PCOS. Keywords: selenium nanoparticles; biochemical tests; histology.