International Journal of Biomedical Nanoscience and Nanotechnology
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International Journal of Biomedical Nanoscience and Nanotechnology (2 papers in press)
Preparation and characterisation of nanofibres from biocellulose and neem-AgNP biocomposites for wound healing by Pandimadevi Muthuraman Abstract: Bacterial cellulose (BC) is secreted by a few strains of bacteria and consists of a cellulose nanofibre network with unique characteristics. In this study, Gluconoacetobacter xylinus was used to isolate bacterial cellulose. Moreover, microbial cellulose have proven to be a remarkably versatile biomaterial and can be used in the paper industry, electronics, wound healing and biomedical devices. The cellulose isolated from G. xylinus was confirmed by biochemical tests. The parameters for the production of cellulose, such as pH, temperature, carbon source, nitrogen source, and growth factor under both static and shaking conditions, were optimised. The obtained cellulose was observed by phase contrast microscopy. The isolated bacterial cellulose is impregnated with silver nanoparticles synthesised by neem leaves extract. The biocellulose and neem-AgNPs were converted into nanofibres by the electrospinning technique. The cellulose-PVA and was analysed by SEM, zeta potential and Fourier transform infrared spectroscopy. This approach can be easily used in the large scale production of silver nanoparticles loaded biocellulose fibres. These fibres can be used in wound dressing and as a biomaterial for scaffolds in tissue engineering. Keywords: biocellulose; nanoparticles; neem leaves; PVA; SEM; zeta potential; FTIR.
The simple method of extra virgin olive oil nanoemulsion for oral consumption: the chance for enteral nanonutrition production by Anna Veterini, Nancy Rehatta, Heni Rachmawati, Annis Adi Abstract: Olive oil phenolic compounds have positive effects on various physiological biomarkers, implicating phenolic compounds as partially responsible for health benefits associated with the Mediterranean diet. The small fraction of extra virgin olive oil was expected to improve the pharmacokinetics of giving olive oil to a critically ill patient. The aim of this research was to improve extra virgin olive oil pharmacokinetics and pharmacodynamics for the critically ill patient who has enteral nutrition absorption disturbance. The nanoemulsion was prepared with self-nano emulsification method by mixing extra virgin olive oil, chremofor RH40, and PEG 400. The optimum formula was obtained from extra virgin olive oil, chremofor RH40, PEG 400 in the ratio of 1: 8 :1. Hence, nanoemulsion is a promising strategy to enhance the potency of extra virgin olive oil . Keywords: extra virgin olive oil nanoemulsion; ultrasonication-mild agitation; nanonutrition.