Title: Immunoproteomics: current approach for subunit vaccine design

Authors: Anant S. Sherkhane; Virendra S. Gomase

Addresses: The Global Open University Nagaland (TGOUN), Indiaand Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India ' The Global Open University Nagaland (TGOUN), Indiaand Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India

Abstract: Immunoproteomics is used to design algorithms for mapping the potential B- and T-cell epitopes, identifying surface-associated proteins and the potential binding sites that lead to the development of new vaccines. This article reviews that the applications of immunoinformatics for designing in silico vaccination the molecular modelling. All these efforts of immunoinproteomics will save time and also reduce the cost. The experimental determination of epitopes is expensive in terms of time, cost, time as well as effort; however, there is need for computational methods for reliable identification of B-cell epitopes. In this review, we use different methods as well as many immunoproteomics algorithms, resources for the prediction of T- and B-cell immune epitopes for epitope vaccine development and protective immunity analysis.

Keywords: proteomics; immunome; MHC; HLA; synthetic peptide vaccines; immunoproteomics; subunit vaccine design; surface-associated proteins; potential binding sites; new vaccines; molecular modelling; B-cell immune epitopes; T-cell immune epitopes; epitope vaccine development; protective immunity analysis.

DOI: 10.1504/IJIS.2014.066845

International Journal of Immunological Studies, 2014 Vol.2 No.1, pp.16 - 28

Received: 16 Oct 2013
Accepted: 15 Mar 2014
Published online: 10 Jan 2015 *

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