Title: Simulation of human renal system

Authors: Haydar A. Mahmood; Nazeih M. Botros

Addresses: College of Engineering-Biomedical Engineering Program, Southern Illinois University Carbondale, Illinois 62901, USA ' College of Engineering-Biomedical Engineering Program, Southern Illinois University Carbondale, Illinois 62901, USA

Abstract: The goal of this study is to develop a synthesisable computer-simulated model that mimics the function of a simplified renal system. Hardware description language has been used to simulate the model. In future phase of this study, the model will be realised on an electronic chip such as 'Field Programmable Gate Arrays'. The simulated model introduces a dynamic representation of the human body fluid balance under normal conditions and displays the change of urine flow with the amount of ingested water. The inputs of the model are average values of parameters extracted from the renal system. Some of these parameters and variables are: arterial pressure, daily ingested fluid volume, daily ingested sodium, daily ingested potassium, extracellular fluid volume, intracellular fluid volume, renin concentration, angiotensin II concentration, and aldosterone concentration. Our results show that the output of the model is in agreement with those of the literatures.

Keywords: renal system; hardware description language; HDL; simulation; mathematical modelling; urine flow; simulation; human body fluid balance; ingested water; kidneys.

DOI: 10.1504/IJCBDD.2013.055462

International Journal of Computational Biology and Drug Design, 2013 Vol.6 No.3, pp.263 - 278

Published online: 29 Jul 2013 *

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