Title: Image-Guided Adaptive Radiation Therapy with anatomic imaging and dose verification in head and neck cancer using kV CBCT

Authors: Maria F. Chan; Yulin Song; Chandra Burman; Yu-Chi Hu; Sang E. Sim

Addresses: Department of Medical Physics, Memorial Sloan-Kettering Cancer Centre, 1275 York Ave., New York, NY 10021, USA. ' Department of Medical Physics, Memorial Sloan-Kettering Cancer Centre, 1275 York Ave., New York, NY 10021, USA. ' Department of Medical Physics, Memorial Sloan-Kettering Cancer Centre, 1275 York Ave., New York, NY 10021, USA. ' Department of Medical Physics, Memorial Sloan-Kettering Cancer Centre, 1275 York Ave., New York, NY 10021, USA. ' Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Centre, 1275 York Ave., New York, NY 10021, USA

Abstract: Image-Guided Adaptive Radiation Therapy (IGART) is a promising approach in radiotherapy for bulky head-and-neck tumours. We have developed a methodology for dosimetric replanning using kV-CBCT. A case study is presented in which the CBCT and planning CT (pCT) images were registered to generate Adaptive pCT (ApCT). The registration similarity measure was intensity-based Mutual Information. The search was optimised using the 'downhill simplex' algorithm. Dose-distribution and DVH were re-calculated. The actual dose delivered can be assessed based on the ApCT. Clinical implementation of IGART has potential to compensate for inter-fractional changes, while reducing damage to critical organs and increasing tumour targeting.

Keywords: IGRT; image-guided radiation therapy; IMRT; intensity-modulated radiation therapy; adaptive radiation therapy; kV cone-beam CT; 4DRT; 4D radiation therapy; head cancer; neck cancer; computed tomography; radiotherapy treatment; tumours; dosimetric replanning; tumour targeting.

DOI: 10.1504/IJBET.2012.046083

International Journal of Biomedical Engineering and Technology, 2012 Vol.8 No.2/3, pp.151 - 166

Available online: 18 Mar 2012 *

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