Title: Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials

Authors: Yingyue Zhu, Wei Chen, Ruirui Qiao, Libing Wang, Chuanlai Xu

Addresses: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu, 214122, China. ' State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu, 214122, China. ' Institute of Chemistry, Chinese Academy of Sciences, Zhong Guan Cun, Bei Yi Jie 2, Beijing 10008, China. ' State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu, 214122, China. ' State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu, 214122, China

Abstract: Introduction. A novel transfection vector was designed to deliver the antisense oligodeoxynucleotide into the cancer cells (HL-60). Methods. Antisense oligodeoxynucleotides (ASODNs) were conjugated to the gold nanoparticles (GNPs) through a chemical reaction. The conjugates were then bound to the single-walled carbon nanotubes (SWNTs). This vector system can effectively for induced apoptosis of the cancer cells. Results. The gold nanoparticles helped to improve both transfection and Raman signal. Conclusions. This vector system can be effective for induced apoptosis of the cancer cells, and thus has the potential to be used as a cancer therapy.

Keywords: single-walled carbon nanotubes; SWNTs; antisense oligodeoxynucleotides; ASODNs; gold nanoparticles; GNPs; transfection vector; multifunctional vectors; cancer therapy; nanotechnology; transfection vectors; cancer cells; induced apoptosis; cancer treatment.

DOI: 10.1504/IJNT.2011.041437

International Journal of Nanotechnology, 2011 Vol.8 No.8/9, pp.664 - 678

Published online: 22 Jul 2011 *

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