Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials
by Yingyue Zhu, Wei Chen, Ruirui Qiao, Libing Wang, Chuanlai Xu
International Journal of Nanotechnology (IJNT), Vol. 8, No. 8/9, 2011

Abstract: Introduction. A novel transfection vector was designed to deliver the antisense oligodeoxynucleotide into the cancer cells (HL-60). Methods. Antisense oligodeoxynucleotides (ASODNs) were conjugated to the gold nanoparticles (GNPs) through a chemical reaction. The conjugates were then bound to the single-walled carbon nanotubes (SWNTs). This vector system can effectively for induced apoptosis of the cancer cells. Results. The gold nanoparticles helped to improve both transfection and Raman signal. Conclusions. This vector system can be effective for induced apoptosis of the cancer cells, and thus has the potential to be used as a cancer therapy.

Online publication date: Fri, 22-Jul-2011

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