Title: Multifunctional nanoparticles: from the detection of biomolecules to the therapy

Authors: Stephane Roux, Olivier Tillement, Claire Billotey, Jean-Luc Coll, Geraldine Le Duc, Christophe A. Marquette, Pascal Perriat

Addresses: Laboratoire de Physico-Chimie des Materiaux Luminescents, Universite Claude Bernard Lyon 1, UMR 5620 CNRS – UCBL, 69622 Villeurbanne Cedex, France. ' Laboratoire de Physico-Chimie des Materiaux Luminescents, Universite Claude Bernard Lyon 1, UMR 5620 CNRS – UCBL, 69622 Villeurbanne Cedex, France. ' Service de medecine nucleaire, Hospices Civils de Lyon, Hopital Edouard Herriot, 69437 Lyon cedex 03, France; Laboratoire LRMN-CREATIS, INSA de Lyon, UMR 5515 CNRS – U630 INSERM – INSA de Lyon, 69622 Villeurbanne Cedex, France. ' Cibles diagnostiques ou therapeutiques et vectorisation de drogues dans les cellules tumorales, CRI-INSERM U823, Institut Albert Bonniot, BP 170, 38 042 Grenoble cedex 9, France. ' ID 17 biomedical Beamline, European Synchrotron Radiation Facility, Polygone Scientifique Louis Neel, 38000 Grenoble, France. ' Institut de Chimie et de Biochimie Moleculaires et Supramoleculaires, Universite Claude Bernard Lyon 1, UMR 5246 CNRS – UCBL, 69622 Villeurbanne Cedex, France. ' Materiaux, Ingenierie et Sciences, INSA de Lyon, UMR 5510 CNRS – INSA de Lyon, 69621 Villeurbanne Cedex, France

Abstract: The intense research activities devoted to nanotechnology led to the development of a wide variety of multifunctional nanoparticles. Besides their small size which opens the route to the exploration of living matter at the subcellular scale, the properties of these particles can be accurately tuned by varying the composition, the size, the shape and the chemical composition of the surface. Some of these particles are peculiarly suited for biological and biomedical applications. This review provides an overview on the sensing and biomedical applications of multifunctional gold and gadolinium oxide nanoparticles which were developed by a network of some laboratories of Rhone-Alpes Region.

Keywords: multifunctional nanoparticles; gadolinium oxide; gold; magnetic resonance imaging; fluorescence imaging; X-ray imaging; radiotherapy; neutron capture therapy; nanotechnology; sensing; biosensors; biomedical applications.

DOI: 10.1504/IJNT.2010.031744

International Journal of Nanotechnology, 2010 Vol.7 No.4/5/6/7/8, pp.781 - 801

Published online: 21 Feb 2010 *

Full-text access for editors Access for subscribers Purchase this article Comment on this article