Article: Low MHC-I density impairs the homeostatic proliferation of CD8 T cells after HSCT Journal: International Journal of Immunological Studies (IJIS) 2009 Vol.1 No.1 pp.13 - 30 Abstract: We hypothesise that the modifications in the Major Histocompatibility Class I (MHC-I) expression after Hematopoietic Stem Cell Transplantation (HSCT) might impact on CD8 T cell recovery. To evaluate our proposal, we measured the number of peripheral CD8 T cells and the MHC-I expression on the monocytes from the patients who underwent allogenic or autologous HSCT. Three months after transplantation, almost all of the autologous recipients showed a high density of MHC-I and the CD8 T cell counts were within the normal range. In contrast, allogeneic recipients had low or heterogeneous expression of MHC-I and low numbers of CD8 T cells. Similar patterns were observed even after 6 to 20 months after transplantation. Recent thymic emigrants and serum levels of IL-7 and IL-15 were similar within both groups of patients. Together, our results indicate that Homeostatic Peripheral Expansion (HPE) is the main mechanism to reach the normal numbers of CD8 T cells immediately after HSCT. A high and homogenous expression of MHC-I molecules is required for an optimal HPE. Inderscience Publishers - linking academia, business and industry through research

Title: Low MHC-I density impairs the homeostatic proliferation of CD8 T cells after HSCT

Authors: Irlanda Olvera-Gomez, Jorge Vela-Ojeda, Vianney Ortiz-Navarrete

Addresses: Departamento de Biomedicina Molecular, Centro de Investigacion y de Estudios Avanzados, Mexico, DF, Mexico. ' Centro Médico La Raza, Torre de Especialidades, Servicio de Hematología, IMSS, Mexico, DF, Mexico. ' Departamento de Biomedicina Molecular, Centro de Investigacion y de Estudios Avanzados, Cinvestav, Av IPN 2508, Col San Pedro Zacatenco, Mexico DF 07360, Mexico

Abstract: We hypothesise that the modifications in the Major Histocompatibility Class I (MHC-I) expression after Hematopoietic Stem Cell Transplantation (HSCT) might impact on CD8 T cell recovery. To evaluate our proposal, we measured the number of peripheral CD8 T cells and the MHC-I expression on the monocytes from the patients who underwent allogenic or autologous HSCT. Three months after transplantation, almost all of the autologous recipients showed a high density of MHC-I and the CD8 T cell counts were within the normal range. In contrast, allogeneic recipients had low or heterogeneous expression of MHC-I and low numbers of CD8 T cells. Similar patterns were observed even after 6 to 20 months after transplantation. Recent thymic emigrants and serum levels of IL-7 and IL-15 were similar within both groups of patients. Together, our results indicate that Homeostatic Peripheral Expansion (HPE) is the main mechanism to reach the normal numbers of CD8 T cells immediately after HSCT. A high and homogenous expression of MHC-I molecules is required for an optimal HPE.

Keywords: major histocompatibility class I; MHC-I density; hematopoietic stem cell transplantation; HSCT; CD8 T cells; homeostatic proliferation; stem cells; cell recovery.

DOI: 10.1504/IJIS.2009.023559

International Journal of Immunological Studies, 2009 Vol.1 No.1, pp.13 - 30

Published online: 28 Feb 2009 *

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Title: Low MHC-I density impairs the homeostatic proliferation of CD8 T cells after HSCT

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