Title: A comprehensive review on magnetic tissue scaffold for hyperthermia treatment

Authors: Debashish Gogoi; Tanyu Donarld Kongnyui; Manjesh Kumar

Addresses: Department of Mechanical Engineering, SRM University AP, Amaravati, India ' Department of Mechanical Engineering, SRM University AP, Amaravati, India ' Department of Mechanical Engineering, SRM University AP, Amaravati, India

Abstract: This review explores the use of magnetic bone tissue scaffolds in hyperthermia treatment. It is a therapy that heats cancer cells to damage or destroy them while minimising harm to healthy tissues. Hyperthermia leverages the greater heat sensitivity of cancer cells, potentially enhancing treatment outcomes. Bone scaffolds, typically composed of biocompatible materials like ceramics or polymers, have emerged as promising tools for hyperthermia by incorporating magnetic nanoparticles that generate heat under an alternating magnetic field. This study aims to evaluate the current advancements in magnetic bone scaffolds for hyperthermia therapy, focusing on the materials, fabrication methods, and magnetic properties that influence their performance. The review also addresses key challenges in optimising scaffold design and offers recommendations for future research to improve therapeutic efficacy. Conclusions indicate that magnetic scaffolds have significant potential for targeted cancer treatment and bone regeneration, yet further studies are needed to enhance their clinical application. This review can guide future efforts toward optimising scaffold-based hyperthermia therapies.

Keywords: hyperthermia treatment; HT; additive manufacturing; cancer; tumour; magnetic properties.

DOI: 10.1504/IJBET.2025.146400

International Journal of Biomedical Engineering and Technology, 2025 Vol.48 No.1, pp.75 - 110

Received: 06 Sep 2024
Accepted: 30 Nov 2024
Published online: 28 May 2025 *

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