Title: Application value of new nano-drug carrier in biphasic 3D-pCASL in the evaluation of cerebral perfusion blood flow in symptomatic and asymptomatic unilateral middle cerebral artery subtotal occlusion

Authors: Lihua Weng; Xuesheng Zheng; Ruigen Pan; Xian Zhang; Jing Jin; Jianju Feng

Addresses: Department of Radiology, Zhuji Affiliated Hospital of Shaoxing University, Zhuji People's Hospital, Zhejiang Province, 311800, China ' Department of Radiology, Zhuji Central Hospital, Zhejiang Province, 311800, China ' Department of Radiology, Zhuji Affiliated Hospital of Shaoxing University, Zhuji People's Hospital, Zhejiang Province, 311800, China ' Department of Radiology, Zhuji Affiliated Hospital of Shaoxing University, Zhuji People's Hospital, Zhejiang Province, 311800, China ' Department of Radiology, Zhuji Affiliated Hospital of Shaoxing University, Zhuji People's Hospital, Zhejiang Province, 311800, China ' Department of Radiology, Zhuji Affiliated Hospital of Shaoxing University, Zhuji People's Hospital, Zhejiang Province, 311800, China

Abstract: We investigate the use of superparamagnetic iron oxide nanoparticles as a contrast agent for the cerebral perfusion of unilateral middle cerebral artery (MCA) subtotal occlusion by magnetic resonance three-dimensional pseudo-continuous arterial spin-labelled imaging (3D-pCASL) dual-phase scanning technology for the application value of blood flow to evaluate the difference of cerebral perfusion between symptomatic and asymptomatic patients. We found through research that the biphasic 3D-pCASL technology can accurately detect cerebral perfusion blood flow in patients with subtotal middle cerebral artery occlusion. Asymptomatic patients have higher cerebral perfusion than symptomatic patients with collateral circulation superparamagnetic iron oxide nanoparticles. Phase (PLD) equal to 1.5 s is more sensitive than 2.5 s, and PLD = 2.5 s can accurately reflect secondary collateral circulation's compensation status.

Keywords: arterial spin labelling; new nano-drugs; superparamagnetic iron oxide nanoparticles; middle cerebral artery occlusion; magnetic resonance perfusion imaging; cerebral blood flow.

DOI: 10.1504/IJNT.2022.128989

International Journal of Nanotechnology, 2022 Vol.19 No.6/7/8/9/10/11, pp.895 - 905

Received: 30 Apr 2021
Accepted: 15 Oct 2021
Published online: 13 Feb 2023 *

Full-text access for editors Full-text access for subscribers Purchase this article Comment on this article