Application value of new nano-drug carrier in biphasic 3D-pCASL in the evaluation of cerebral perfusion blood flow in symptomatic and asymptomatic unilateral middle cerebral artery subtotal occlusion Online publication date: Mon, 13-Feb-2023
by Lihua Weng; Xuesheng Zheng; Ruigen Pan; Xian Zhang; Jing Jin; Jianju Feng
International Journal of Nanotechnology (IJNT), Vol. 19, No. 6/7/8/9/10/11, 2022
Abstract: We investigate the use of superparamagnetic iron oxide nanoparticles as a contrast agent for the cerebral perfusion of unilateral middle cerebral artery (MCA) subtotal occlusion by magnetic resonance three-dimensional pseudo-continuous arterial spin-labelled imaging (3D-pCASL) dual-phase scanning technology for the application value of blood flow to evaluate the difference of cerebral perfusion between symptomatic and asymptomatic patients. We found through research that the biphasic 3D-pCASL technology can accurately detect cerebral perfusion blood flow in patients with subtotal middle cerebral artery occlusion. Asymptomatic patients have higher cerebral perfusion than symptomatic patients with collateral circulation superparamagnetic iron oxide nanoparticles. Phase (PLD) equal to 1.5 s is more sensitive than 2.5 s, and PLD = 2.5 s can accurately reflect secondary collateral circulation's compensation status.
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