Article: Study on vitro transdermal administration of surface anaesthetics based on dextran-based nano-injection lipid lidocaine Journal: International Journal of Nanotechnology (IJNT) 2022 Vol.19 No.6/7/8/9/10/11 pp.601 - 609 Abstract: The paper explored the in vitro transdermal performance and in vivo characteristics of surface anaesthetics containing lidocaine (LID-HLD-BNs) using dextran-based nanoliposome as a carrier. Methods: The paper used lidocaine-encapsulated traditional liposomes (LID-CLs) and lidocaine hydrochloride injection (LID-IJ) as controls, using isolated mouse abdominal skin, using Franz diffusion cell, high-performance liquid Chromatographic method was used to conduct in vitro transdermal experiments to observe the transdermal performance of LID-HLD-BNs. Using calcian as a probe, using laser confocal microscope (CLSM), with calcian-loading traditional liposomes (calcian-CLs) and free calcian as controls, observe the liposome preparation (calcian-HLD-BNs) Fluorescence penetration in the abdomen of living mice. Results: The study found that LID-HLD-BNS' cumulative transdermal volume per unit area and transdermal rate were higher than LID-CLs and LID-IJ. The transdermal rates of LID-IJ, LID-CLs, and LID-HLD-BNs were 39.15, 79.04, and 142.86 μg/(cm2·h), respectively, and the difference was statistically significant (P < 0.01). In the in vivo fluorescence transdermal experiment, the skin penetration speed and depth of the calcian-HLD-BNs group were significantly greater than those of the calcian-CLs group and the free calcian group. Conclusion: Dextran-based nanoliposomes have good transdermal permeability. Inderscience Publishers - linking academia, business and industry through research

Title: Study on vitro transdermal administration of surface anaesthetics based on dextran-based nano-injection lipid lidocaine

Authors: Na He

Addresses: Department of Anesthesiology, The Affiliated Hospital Inner Mongolia Medical University, Hohhot 010110, China

Abstract: The paper explored the in vitro transdermal performance and in vivo characteristics of surface anaesthetics containing lidocaine (LID-HLD-BNs) using dextran-based nanoliposome as a carrier. Methods: The paper used lidocaine-encapsulated traditional liposomes (LID-CLs) and lidocaine hydrochloride injection (LID-IJ) as controls, using isolated mouse abdominal skin, using Franz diffusion cell, high-performance liquid Chromatographic method was used to conduct in vitro transdermal experiments to observe the transdermal performance of LID-HLD-BNs. Using calcian as a probe, using laser confocal microscope (CLSM), with calcian-loading traditional liposomes (calcian-CLs) and free calcian as controls, observe the liposome preparation (calcian-HLD-BNs) Fluorescence penetration in the abdomen of living mice. Results: The study found that LID-HLD-BNS' cumulative transdermal volume per unit area and transdermal rate were higher than LID-CLs and LID-IJ. The transdermal rates of LID-IJ, LID-CLs, and LID-HLD-BNs were 39.15, 79.04, and 142.86 μg/(cm2·h), respectively, and the difference was statistically significant (P < 0.01). In the in vivo fluorescence transdermal experiment, the skin penetration speed and depth of the calcian-HLD-BNs group were significantly greater than those of the calcian-CLs group and the free calcian group. Conclusion: Dextran-based nanoliposomes have good transdermal permeability.

Keywords: dextran-based nanoparticles; liposomes; lidocaine; chromatography; transdermal administration; in vitro studies.

DOI: 10.1504/IJNT.2022.128965

International Journal of Nanotechnology, 2022 Vol.19 No.6/7/8/9/10/11, pp.601 - 609

Received: 30 Apr 2021
Accepted: 08 Jul 2021
Published online: 13 Feb 2023 *

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Title: Study on vitro transdermal administration of surface anaesthetics based on dextran-based nano-injection lipid lidocaine

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