Article: Numerical assessment of a 3D human upper respiratory tract model: effect of anatomical structure on asymmetric tidal pulmonary ventilation characteristics Journal: International Journal of Biomedical Engineering and Technology (IJBET) 2022 Vol.38 No.3 pp.225 - 248 Abstract: The analysis of airway ventilation characteristic is important for diagnosis and pathological assistance for respiratory diseases. It is therefore imperative to study the impact of anatomical features on the internal flow field. The article is focused on an in-silico study on impact of anatomical structure of human upper respiratory tract on transient asymmetric tidal pulmonary ventilation characteristics. Therefore, a three-dimensional human airways model is reconstructed from nasal cavity up to seventh generation bronchi from computed tomography (CT) images of a 48-year-old healthy man using computational modelling technique. A validated low Reynolds number (LRN) realisable <i>k</i> - <i>ε</i> turbulence model is used to capture the internal flow mixed turbulence characteristics. The numerical simulations were performed for asymmetric low and high tidal pulmonary ventilation (ALTPV, 10 L/min and AHTPV, 40 L/min). The numerical analysis assists to predict the near realistic airway ventilation phenomena and internal flow physics in the upper respiratory tract. Inderscience Publishers - linking academia, business and industry through research

Title: Numerical assessment of a 3D human upper respiratory tract model: effect of anatomical structure on asymmetric tidal pulmonary ventilation characteristics

Authors: Digamber Singh; Anuj Jain; Akshoy Ranjan Paul

Addresses: Motilal Nehru National Institute of Technology Allahabad, Prayagraj, 211004, India ' Motilal Nehru National Institute of Technology Allahabad, Prayagraj, 211004, India ' Motilal Nehru National Institute of Technology Allahabad, Prayagraj, 211004, India

Abstract: The analysis of airway ventilation characteristic is important for diagnosis and pathological assistance for respiratory diseases. It is therefore imperative to study the impact of anatomical features on the internal flow field. The article is focused on an in-silico study on impact of anatomical structure of human upper respiratory tract on transient asymmetric tidal pulmonary ventilation characteristics. Therefore, a three-dimensional human airways model is reconstructed from nasal cavity up to seventh generation bronchi from computed tomography (CT) images of a 48-year-old healthy man using computational modelling technique. A validated low Reynolds number (LRN) realisable k - ε turbulence model is used to capture the internal flow mixed turbulence characteristics. The numerical simulations were performed for asymmetric low and high tidal pulmonary ventilation (ALTPV, 10 L/min and AHTPV, 40 L/min). The numerical analysis assists to predict the near realistic airway ventilation phenomena and internal flow physics in the upper respiratory tract.

Keywords: ALTPV; AHTPV; computed tomography; CT; computational fluid dynamics; CFD; transient; wall shear stress; WSS; human upper respiratory tract; HURT; LRN k - ε turbulence model.

DOI: 10.1504/IJBET.2022.121738

International Journal of Biomedical Engineering and Technology, 2022 Vol.38 No.3, pp.225 - 248

Received: 24 Sep 2018
Accepted: 18 Dec 2018
Published online: 07 Apr 2022 *

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Title: Numerical assessment of a 3D human upper respiratory tract model: effect of anatomical structure on asymmetric tidal pulmonary ventilation characteristics

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