Title: Inter k-shell connectivity: a novel computational approach to identify drug targets

Authors: Praveen Kumar Singh

Addresses: Department of Bioinformatics, Maulana Azad National Institute of Technology, Bhopal, 462042, India

Abstract: Central lethality rule suggests that hub proteins are the most important and their deletion leads to more damage to biological networks as compared to non-hub proteins. Hub proteins present towards the core of protein-protein interaction (PPI) network are considered to be more important in comparison to proteins at the periphery. The k-shell decomposition method generates k-shell index which indicates the local and global importance of a protein in PPI network. But there is no method till now reported which can differentiate among the proteins with same k-shell index. In this work attempt has been made to add parameter Inter k-shell connectivity to differentiate proteins with same k-shell index and exploring their biological importance.

Keywords: centrality lethality rule; protein networks; k-shell decomposition; Mycobacterium.

DOI: 10.1504/IJCBDD.2020.107890

International Journal of Computational Biology and Drug Design, 2020 Vol.13 No.3, pp.272 - 281

Received: 26 Jan 2019
Accepted: 16 Apr 2019

Published online: 30 Jun 2020 *

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