Title: Inter k-shell connectivity: a novel computational approach to identify drug targets
Authors: Praveen Kumar Singh
Addresses: Department of Bioinformatics, Maulana Azad National Institute of Technology, Bhopal, 462042, India
Abstract: Central lethality rule suggests that hub proteins are the most important and their deletion leads to more damage to biological networks as compared to non-hub proteins. Hub proteins present towards the core of protein-protein interaction (PPI) network are considered to be more important in comparison to proteins at the periphery. The k-shell decomposition method generates k-shell index which indicates the local and global importance of a protein in PPI network. But there is no method till now reported which can differentiate among the proteins with same k-shell index. In this work attempt has been made to add parameter Inter k-shell connectivity to differentiate proteins with same k-shell index and exploring their biological importance.
Keywords: centrality lethality rule; protein networks; k-shell decomposition; Mycobacterium.
International Journal of Computational Biology and Drug Design, 2020 Vol.13 No.3, pp.272 - 281
Received: 26 Jan 2019
Accepted: 16 Apr 2019
Published online: 30 Jun 2020 *