Inter k-shell connectivity: a novel computational approach to identify drug targets
by Praveen Kumar Singh
International Journal of Computational Biology and Drug Design (IJCBDD), Vol. 13, No. 3, 2020

Abstract: Central lethality rule suggests that hub proteins are the most important and their deletion leads to more damage to biological networks as compared to non-hub proteins. Hub proteins present towards the core of protein-protein interaction (PPI) network are considered to be more important in comparison to proteins at the periphery. The k-shell decomposition method generates k-shell index which indicates the local and global importance of a protein in PPI network. But there is no method till now reported which can differentiate among the proteins with same k-shell index. In this work attempt has been made to add parameter Inter k-shell connectivity to differentiate proteins with same k-shell index and exploring their biological importance.

Online publication date: Tue, 30-Jun-2020

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