Metalexyl fungicide induced oxidative stress and apoptosis in mouse thymus: the effect of antox
by Saber A. Sakr, Hawazen A. Lamfon
International Journal of Immunological Studies (IJIS), Vol. 1, No. 2, 2010

Abstract: Metalaxyl is a benzenoid fungicide used to control soil-borne fungal diseases on fruits, cotton, soybean, peanuts, ornamental and grasses. The present work aims to evaluate the effect of oxidative stress on the induction of apoptosis in thymocytes of mice by metalaxyl. The work extends to study the possible role played by antox in minimising the toxicity of metalaxyl. Thymus of metalexyl-treated mice showed many histopathological alterations. There was a loss of differentiation between region of cortex and medulla, abnormal arrangement of lymphocytes and degeneration of the trabecula. Treatment with metalaxyl leads to an increase in apoptotic rate of thymocytes as detected by flow cytometry. Moreover, metalaxyle administration to animals increased significantly malondialdehyde and decreased catalase activity. The results showed that treating animals with metalaxyl followed by antox revealed an improvement in the histological changes observed in animals treated with metalaxyl alone. Moreover, antox treatment leads to a decrease in the percent of apoptotic cells. A decrease of malondialdehyde level and increase of catalase activity was recorded.

Online publication date: Mon, 30-Aug-2010

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Immunological Studies (IJIS):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com