Forthcoming articles

 


International Journal of Medical Engineering and Informatics

 

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International Journal of Medical Engineering and Informatics (56 papers in press)

 

Regular Issues

 

  • Learn Quest A Virtual Reality based system for training Autistic Kids   Order a copy of this article
    by Shriram K Vasudevan, Abhishek S N, Swathi S, Akshaya Lakshmi, Anandram S 
    Abstract: Childhood is the best part of life. A child enjoys anything and everything in this world without any discriminations. It is also the period of rapid brain development, where the kids learn the stepping stones for life. Autism Spectrum Disorder (ASD) is a group of developmental disabilities that causes major impairments in social, communication and behavioral aspects of the children. Unlike other children, an autistic kid finds it difficult to go along and communicate with others. Social interactions and communication are the major aspects for peaceful living of any human being, and these children face difficulties in the same. So, we have developed a virtual reality based game engine that would attract the children and make them enjoy interacting with it while increasing the chance for learning. As the children continues playing this game, their learning and interacting ability increases nullifying some effects of autism, thus making it a boon for these kids.
    Keywords: Virtual Reality; Autism; 3D; game; interaction; Gesture; Leap Motion Sensor.

  • Mechanics of the septal wall may be affected by the presence fibrotic infarct in the free wall at end-systole   Order a copy of this article
    by Fulufhelo Nemavhola 
    Abstract: The relationship between infarct mechanics and ventricular function of septal wall in the presence of fibrotic infarct in the free wall remains poorly understood. This study compares the mechanics of the septal wall in the healthy and fibrotic infarcted rat hearts models during active ejection. Finite element models of rat heart were developed to study the ventricular mechanics of the septal wall in the presence of fibrotic infarct in the left ventricular free wall. To simulate active contraction, three dimensional constitutive Fung model was implemented in Abaqus
    Keywords: septal wall; myocardial mechanics; heart computational models; fibrotic infarct; infarct modelling.

  • Optimized DBN for Effective Enhancement of Ultrasound Images with pelvic Lesions   Order a copy of this article
    by Sandanand L. Shelgaonkar, Anil B. Nandgaonkar 
    Abstract: Nowadays, the ultrasound modality is the current research areas for lesion analysis. Moreover, it is renowned; the ultrasound images exhibit hassle- free utilization as well as cost effectiveness. In the literature, merely a small number of reliable contributions have been reported from the females for analyzing the pelvic lesions. However, the literature lags with adopting a prominent enhancement procedure to facilitate the diagnosis process. This paper adopts an Optimized Deep Belief Neural (ODBN) network for enhancing the US image of pelvic portions. It considers the higher order as well as lower order statistical characteristics of the image to define the appropriate filter band for image enhancement. The lower order features are optimized to use with the higher order features so that the optimal usage of features is reported here. To optimize the lower order features, an advanced optimization search algorithm named Grey Wolf Optimizer algorithm (GWO) is exploited. The ODBN learns the optimized features and the noise characteristics for precise prediction of the filter bands, which enhance the image substantially over the conventional filter bands. The performance of the proposed method is compared with the conventional methods using the benchmark as well as real-time US images of pelvic lesions. The quality of enhancement is ensured using the renowned measures such as PSNR and ESSIM that exhibit the performance of the proposed approach.
    Keywords: ultrasound; PSNR; ESSIM; GWO; DBN.

  • An innovative technical solution to avoid Insomnia and Noise-Induced Hearing Loss   Order a copy of this article
    by Shriram K V, Ikram Shah, Sriharsha Patallapalli, Karthikeyan S, S. Subhash Chandran, U. Adithya Bharadwaj 
    Abstract: The major challenge these days with the increased usage of the mobile phone is loss of sleep (insomnia), increased stress and finally more damages to the health and mental wellness. Most of us have the habit of even keeping the phone underneath the pillow while sleeping. There are people who are now treated for mobile addiction. People are there to use a phone to get sleep sooner. Sleep time is meant for the brain to rejuvenate, organize thoughts and relax. If the sleep patterns are disturbed due to a continuous external commotion, it will result in the subconscious to spend energy and brain space. Hence, it is wise to switch off the music after the person sleeps which most of us do not do as we are already slept by then. Also, wearing headphones for an hour will increase the bacteria in your ears by 700 times. Many researches in the past prove that music is a solution to reduce stress and to bring sleep. But, we, the users are using headphones for music and it causes some dangerous side effects including affecting the sleep and noise-induced hearing loss. There is a strong need to avoid unnecessary health problems which are meant to be avoided. Here, we propose a system which will ensure that the music player is stopped after understanding that the person using it has slept and he no more needs the tunes thereby not disturbing the deep sleep and preventing insomnia and noise-induced hearing loss. Novelty is what we present in this research through making sure if the person has really slept or not. Our innovative system switches off the audio automatically when a person falls asleep. The same can be expanded and improvised to provide analytics to the user as in how many hours did he sleep peacefully, how is his body tuned towards listening to music, how long does he need music, under what conditions does he over listen or under listen etc.
    Keywords: Sleep monitoring; Headphones/ Earphones ; Wearables; Heart rate ; Pulse; Mobile Application; Multimedia Playing; Insomnia; NIHL.

  • Health Panel: a Platform Useful to Physicians for Fast and Easy Managing of FPGA-based Medical Devices   Order a copy of this article
    by Agostino Giorgio 
    Abstract: The Design of Medical Devices is frequently based\r\non Field Programmable Gate Arrays (FPGAs). This is especially\r\ndue to their unique properties in order to fast prototyping and\r\ntheir great capabilities in Digital Signal Processing (DSP). The\r\nproblem arises to make physicians able to manage such devices\r\nespecially to set and program during prototyping, experimental\r\nand validation processes of new medical devices. Therefore, the\r\nobjective of this paper is the description of a platform, named\r\nHealth Panel, in its hardware and software components,\r\novercoming these issues. The design methods and the test and\r\ndebug methods are also detailed. The hardware is an Embedded\r\nSystem (ES) and the software, developed in Matlab environment,\r\nacts as user friendly interface making the physician able to\r\nmanage quick and easy the FPGA. Results of tests and of an\r\naccurate debug of the platform are described. The platform aims\r\nat providing a significance contribution for designing hardware\r\nand software interfaces for an easy and quick use of FPGA-based\r\nmedical devices. Conclusions and final remarks provide\r\nsuggestions for future developments of the platform.
    Keywords: FPGA; Embedded Systems; Digital Signal Processing; Matlab; Medical Devices; Electrocardiogram, Auscultation.

  • Spectro-Temporal Analysis of Electromyogram Signals (EMGs)   Order a copy of this article
    by Meziani Fadia, Rerbal Souhila, Debbal Sidi Mohammed El Amine 
    Abstract: Electromyography (EMG) signals can be used for clinical/biomedical applications. Is a very important biomedical signal that measures electrical currents generated in muscles during its contraction representing neuromuscular. Individual muscle fiber action potentials are sometimes acquired using wire or needle electrodes placed directly in the muscle. The combination of the muscle fiber action potentials from all the muscle fibers of a single motor unit is the motor unit action potential (MUAP) which can be detected by a skin surface electrode (non-invasive) located near this field, or by a needle electrode (invasive) inserted in the muscle. The simple detection with electrodes has been recognized for a long time as an important tool for the diagnosis of neuromuscular diseases, although its accuracy is still insufficient to diagnose some neuromuscular diseases (Myopathy and Neuropathy). It does not enable the analyst to obtain both qualitative and quantitative characteristics of the EMG signals. The efficiency of diagnosis can be improved considerably by using modern digital signal processing techniques. Therefore, these last can provide useful and valuable information on these signals. The aim of this study is to analyse EMGs signals using temporal and frequency analysis. This analysis is based on temporal parameters such as :amplitude, energy, entropy... and frequency parameter such as median frequency and mean frequency by using the FFT and the non-linear information by using the bispectrum analysis , can provide a wide range of informations related to the type of signal (normal and pathological).
    Keywords: Electomyogram; EMG; signal; time-frequency; analysis; parameters; pathology.

  • Generating a stable primary schedule for an integrated surgical suite   Order a copy of this article
    by Asie Soudi, Mehdi Heydari 
    Abstract: Efficient utilization of operating room (OR) is a common anxiety of surgical suit manager which necessitate an effective planning and scheduling of surgeries. In this paper we investigate predictive / reactive scheduling of an integrated surgical suite in the form of a two-stage hybrid flow shop scheduling problem (HFSP). The deterministic model comprises both assignment and sequencing decisions for elective surgeries. By further considering shared capacity between elective and emergency patients, a chance constrained programming model is extended for the first time to cope with uncertain disruption. It is shown that how a chance constrained model will reduce to just considering an augmented surgery which processing time depends on distribution function of emergency surgery processing time and confidence level of scheduler. Two new important measures in reactive scheduling literature, 'stability' and 'robustness' are taking into account in surgical suite scheduling for the first time. Computational results demonstrate the efficiency of primary schedule generated by extended chance constrained programming model as well as the effectiveness of new measures in hospitals. As the chance constrained model is NP-hard, a decomposition heuristic algorithm based on tabu search (TS) is proposed to cope with problems of real size.
    Keywords: Stability and robustness; predictive / reactive scheduling; hybrid flow shop; integrated surgical suite.

  • Adaptive Improved Binary PSO Based Learnable Bayesian Classifier for Dimensionality Reduced Microarray Data   Order a copy of this article
    by Barnali Sahu, Satchidananda Dehuri, Alok Jagadev 
    Abstract: This article presents, an adaptive improved binary particle swarm optimization based learnable Bayesian classifier for dimensionally reduced microarray data. In the first fold of this two-folded work, the problem of dimension is reduced by unsupervised method of feature reduction. We apply k-means clustering algorithm on the microarray data to group functionally redundant genes followed by application of signal-to-noise-ratio ranking technique to generate an intermediate feature subset consisting of most relevant and non-redundant feature subsets. In the second fold, the feature subset has been given to adaptive binary particle swarm optimization based learnable Bayesian classifier for simultaneous selection of features and classification. We conduct an extensive experimental work on a few benchmark datasets to validate its classification accuracy with and without reducing the dimensionality of micro-array data. It was observed that our method is not only accepted as a good classifier over methods, which are considered here for comparison but also be treated as an alternative method of reducing dimension of the problem.
    Keywords: Microarray data; Feature selection; Signal-to-Noise-Ratio; Classification; Bayesian classifier; Adaptive PSO.

  • Product Unit Neural Network trained by an Evolutionary Algorithm for diabetes disease diagnosis   Order a copy of this article
    by Radhwane BENALI, Nabil Dib, Fethi Bereksi Reguig 
    Abstract: Diabetes disease occurs when the level of glucose in the blood becomes higher than normal because the body is unable to produce the insulin which is needed to regulate glucose. In this study, a new classification method for the diagnosis of diabetes disease was developed. This method is based on a special class of neural network known as product-unit neural networks (PUNN) which was trained by an evolutionary algorithm (EA). We have used EA in order to determine the basic topology of the structure of the PUNN, and to estimate its coefficients weights. The performances of the proposed classifier were evaluated through the sensitivity, the specificity and the classification accuracy using both conventional and 10-fold cross-validation method using the Pima Indian Diabetes (PID) dataset. Obtained results reveal that the proposed approach outperforms several famous and recent methods existing in the literature for diabetes disease diagnosis.
    Keywords: Product Unit Neural Network (PUNN); Evolutionary Algorithms (EA); Diabetes disease diagnosis; Pima Indian diabetes (PID).

  • Development of a Serious Game to Enhance Assistive Rehabilitation   Order a copy of this article
    by Mauro Bellone, Andrea Martini, Francesco Argese, Piero Cirillo, Italo Spada, Antonio Cerasa 
    Abstract: The aim of this study is to investigate novel assistive technologies based on serious gaming for the assessment of postural control and motor rehabilitation. Previous research already demonstrated that rehabilitation and physical activities can improve the quality of life of patients, and virtual reality applications may act as good additional companions during the therapeutic sessions. Indeed, workout routines supported by serious gaming encourage patients to train harder, bringing the therapy towards a pleasant game into a virtual environment. During the game, sensors track the movements of the players and transfer the data to software components that record a database from which patients progress can be determined. The acquired measures are interpreted in the form of new biomarkers, which enable the assessment of postural control. Such biomarkers are based on a probabilistic approach and show the capability to discriminate between well-performed exercises and incorrect movements. A long-term experimentation on a specific exercise is proposed, showing a considerable improvement, ranging from 5\% to 30\%, in the performance of patients.
    Keywords: rehabilitation; virtual reality; motor inabilities; visual tracking; assistive technologies.
    DOI: 10.1504/IJMEI.2019.10012730
     
  • An Evaluation of Released Mobile Health Apps in Popular Iranian App Stores   Order a copy of this article
    by Hamid Naderi, Kobra Etminani 
    Abstract: The rapid growth in development and using mobile health applications had significant potential in the field of health. The study objective was to describe apps in the most popular Iranian Android and IOS app stores. Detail information of apps were extracted, categorized by subject and descriptive analyses were done. 3331 android and 277 IOS apps were remained for study. 88% of popular android mHealth apps were free on the other hand 70% of popular IOS apps were paid. The average price of android and IOS paid apps were $0.37 and $6.55. The average of rating value for all android subcategories (total average 4.33) is higher than IOS subcategories (total average 3.58). Our study confirmed fitness was the most popular topic. The average of rating value for all android subcategories was higher than IOS subcategories. It seems large number of mHealth app users preferred using applications which can update their content continuously.
    Keywords: mHealth; Iranian app stores; Mobile applications; Descriptive analysis.

  • Digital Watermarking in Medical Imaging: A Review   Order a copy of this article
    by Hana Ouazzane, Hela Mahersia, Kamel Hamrouni 
    Abstract: This paper presents considerations on the digital watermarking potential to fit within the medical imaging field. We aim to identify watermarking applications and main strategies within different approaches through previous works. An analysis and evaluation of previous literature quality is also established. We conclude that digital watermarking has considerable purposes in the medical imaging field, it joins and complements existing security measures and management tools for medical images.
    Keywords: digital watermarking; fragile/semi-fragile watermarking; robust watermarking; lossless watermarking; medical imaging; content security; e-health; medical information systems.

  • An Innovative Solution for prevention of reverse flow of blood in IV set (Intravenous set) using Embedded Systems   Order a copy of this article
    by Abhishek SN, Ikram Shah, K.V. Shriram 
    Abstract: The demand for medicine and doctors is never ending and it is really evergreen as our society has been revolutionized and the life expectancy rate has increased. Everyone starting from a six year old child to 90 year old veteran is aware of all kind of diseases exists as of now, specialization of doctors, which doctor to approach when we have a particular problem and so on. Thus, a common wish prevailing in everyone irrespective of age is that to live long and stay in pink of health. Adding to this point, millions and millions of innovations are being made in the medicinal field every decade to enhance the average life expectancy rate. There are various sectors of engineering that are involved in creating and/or maintaining various medical instruments. Say, from the smallest equipment like syringe to the largest one like CT scan machine have major contributions from the engineering sectors. IV Set (Intravenous set) is one among those substantial inventions in the medicinal field; it is actually used for transferring blood or saline from the IV/fluid bag to the patients body at a speed and pressure that the human body can accept. There is a notable threat associated with using the IV set which most of the doctors and care takers are aware of; When the fluid in the IV bag runs out (gets emptied) the patients blood would start flowing through the IV tube in the reverse direction towards the empty IV bag as the pressure of blood in the human body is more than the pressure experienced by the empty IV bag (diffusion), thus leading to blood loss and pain, at times. Thus the caretakers must be vigilant enough to replace the fluid bag at an appropriate time to avoid blood loss. The innovation proposed here is a solution that would prevent such blood losses and doesnt require manual monitoring of the IV bag thereby stopping the reverse blood flow well in time. This not only prevents blood loss but also reduces the stress for the care takers and pain for the patients. The product is tested and is costing less than 100 USD and is one-time investment for the hospitals.
    Keywords: Intravenous set; Blood loss; intelligent IV Set; Hospitals; Medicine; Saline; Intelligent medical support; Patient monitor;.

  • Identification of Important Biomarkers for Detection of Chronic Kidney Disease using Feature Selection and Classification Algorithms   Order a copy of this article
    by E. Sivasankar, Pradeep R, Sivanandham S 
    Abstract: Health informatics plays a critical role to discover, innovate and reform the healthcare system towards betterment by fostering a collaboration between patients' data and medical practices. Development of easy, accurate and convenient methods for detection of diseases is a growing field of study in health informatics because of its easy scalability and affordability. In this paper, we have tried to identify important biomarkers for the detection of Chronic Kidney Diseases. We have used filter and wrapper based feature selection techniques and four different classification methods to analyse and interpret data to help us diagnose Chronic Kidney Disease faster. We have reported the top attributes and their predictive accuracy in detecting CKD and Support Vector Machine with Chi-squared feature selection method provided us with the best accuracy.
    Keywords: Chronic kidney disease; CKD; Feature selection; Classification; Detection predictive model; Biomarkers for CKD; Risk factors; Machine learning; glomerular filtration rate; GFR; Nephrology.

  • Discrimination of signals phonocardiograms by using SNR report   Order a copy of this article
    by Mostefa Meriem, Hamza Cherif Lotfi, Debbal Sidi Mohammed El Amine 
    Abstract: The phonocardiographic PCG signal presents the acoustic recording of heart sounds; witch may reveal significant information that the human ear cannot. The current study develops methods for classification of signals using wavelet transform PCG, in Particular, the discrete wavelet transforms (DWT). In every case of PCG signal, different degree of noise will be gradually added and Ratio Signal to Noise (SNR) is Calculated. The intensity of the (SNR) is the basic parameter used in the classification of signals PCG.
    Keywords: Phonocardiogram; Discrete wavelet transforms; SNR; Sound; ER.

  • An inventive and innovative system to detect fall of old aged persons A novel attempt with IoT, Sensors and Data Analytics to prevent the post-fall effects.   Order a copy of this article
    by Juluru Anudeep, Gudimetla Kowshik, Popuri Vamsi Krishna, Ikram Shah, K.V. Shriram 
    Abstract: According to the statistics of NCOA (National Council on Aging) these days rate of deaths in the old aged people has reached a critical state that for every 11 seconds an older adult is being treated for a fall and for every 19 minutes a death is taking place. Most of the old aged people are suffering from the back pain, joint pain, knee pain and they mostly are the ones who arent able to walk properly and are mostly constrained to bed. Statistics by north eastern Ohio state reveals that, the rate of emergency room treatment of fall-related injuries in persons aged 75 and older approached 80 per 1,000 per year in women and 60 per 1,000 per year in men. Falls are indications to some critical problems like immobility, fragility of bones and chronic health impairment. Falls in elders vary from that of the falls in kids, as the healing power in the old people slackens with their age. Falls are going to play a crucial role in the health line of the old people. Due to the falls there will even be a huge impact on the heart. Old people with heart diseases when falls suddenly, there is risk of being affected by Tachyarrhythmia which is typically a heart disorder in which the heartbeat raises to an abnormal rate of more than 100 beats per minute which is approximal to an cardiac arrest. So, in order to reduce these type of risks in elderly people , We present a frugal and affordable system that could monitor the motion of the old people and can detect their fall. Detection is not done before the fall or when person remains in rest state, it detects immediately after fall and alerts the concerned persons to do the necessary action to save the person. We use IoT, Sensors and Data analytics to build this system. The system is tested for its functioning and is fool proof.
    Keywords: Fall detection; Old age support; IoT; IoT for medicine; Old aged tracking system; Gyroscope;.

  • Pragmatic Realities on Brain Imaging Techniques and Image Fusion for Alzheimers Disease   Order a copy of this article
    by P.S.Jagadeesh Kumar, Yang Yung, Mingmin Pan 
    Abstract: Alzheimers Disease is the absolute generous of age-related neurodegenerative syndrome. It specifies substantial brain atrophy, amnesia and major neuro-logic disintegration. Brain imaging techniques has been progressively employed for medical explanation and variant diagnosis, and to afford understanding into the paraphernalia on functional and structural measurements of the brain, sketches of dimensional distribution besides their normal antiquity and progression over time. This paper makes an exertion in performing a practical virtuosity on brain imaging techniques and image fusion for the diagnosis of alzheimers Disease. Several brain imaging techniques like computerized tomography, single-photon emission computed tomography, magnetic resonance spectroscopy, positron emission tomography, magnetoencephalography, magnetic resonance imaging diffusion tensor imaging was evaluated for alzheimers disease based on their degree of confidence, quality, volumetry, availability, cost and limitations.
    Keywords: Alzheimer’s Disease; Brain Imaging Techniques; Image Fusion; Performancer Evaluation; Neurodegenerative Syndrome.

  • An Artificial Intelligence approach for the recognition of early stages of - ECZEMA   Order a copy of this article
    by Dhananjay Kalbande, Rohit Naik, Janvi Jatakia, Uday Khopkar 
    Abstract: The rural population of India currently suffers from various medical ailments and due to the lack of medical facilities and practitioners, enough support is not available. Medical help might come late and in the meanwhile, the problem might have been aggravated. In usual cases, it might not be possible to provide high-quality medical help, but nowadays, with the world advancing technologically, almost everything seems within reach. With the increasing awareness about artificial intelligence, mobile computing, and the trend of image classification, it is now possible to solve these problems using technology. The research aims at detecting an early stage of the skin disease Eczema in individuals, when the affected part of the human body is captured as an image through a smart phone device and approximate symptoms are provided by the medical practitioner. It uses Artificial Intelligence algorithms like Convolutional Neural Networks and Support Vector Machines Algorithms for classifying the images, and Back Propagation algorithm for training a model based on the symptoms. Around 50 Clinical photographs of Eczema acquired from Department of Skin andV.D of Seth G.S.M.C&KEMHospital, Mumbai were used to train the classifier and then different images were tested for the disease with an accuracy of greater than 85%.
    Keywords: Artificial Intelligence; Backpropagation Network; ConvolutionalrnNeural Network; Support Vector Machine.

  • Transmission and Archiving of Reduced MRI Medical Images   Order a copy of this article
    by Hedi AMRI, Med Karim ABDMOULEH, Ali KHALFALLAH, Jean-Christophe LAPAYRE, Med Salim BOUHLEL 
    Abstract: Medical images are often large. To minimize their file sizes, different compression standards like JPEG, JPEG 2000 and TIFF have been developed, but they can affect the image quality in case of lossy compression. In this paper, we propose a compression method based on image resizing that can reduce the file size to a quarter before its transmission or archiving. When it is received or before its display, the reduced image is enlarged to ensure better visual comfort. This approach is called REPro. In this context, we have used three image reduction techniques namely Square-Square Mesh Decimation, Square-Square filtered Mesh Decimation, the Square-Staggered-Square filtered Mesh Decimation. In addition, we have utilized four enlargement techniques namely Zero padding, Nearest Neighbor interpolation, Cubic Spline interpolation and B-interpolation to resize MRI images. The experimental results prove that the combination of the Square-Square Mesh Decimation with the B-Spline interpolation ensures the minimum distortion of the original image.
    Keywords: Telemedicine; Archiving; Transmission; Medical images; image Reduction; image Expansion.

  • Breast Cancer Detection in Mammogram image with Segmentation of Tumor Region   Order a copy of this article
    by Vikramathithan A C, Dandinashivara Revanna Shashikumar 
    Abstract: In our proposed breast cancer malignant detection study are performed with the aid of fuzzy min max neural network technique. Majority of womens are affected in this breast cancer at a early stage the mammogram images are mostly play in a vital role. Initially the input mammogram image smoothened with the aid of adaptive median filer from that smoothened image we are segmenting tissues with the aid of Histon based Fuzzy c-means clustering. We are extracting features from that segmented image the features are statistical and semantic features. Then we can identify the malignant region with the aid of these features. The segmented region is maligned or benign using an optimal fuzzy min max neural network with gray wolf optimization algorithm with the aid of these we will identify a breast cancer region.
    Keywords: Breast Cancer; Mammogram; Fuzzy min max; gray wolf; optimization; segmentation.

  • Radial Basis Function Neural Network with Genetic Algorithm for Discrimination of Recombination Hotspots in Saccharomyces Cerevisiae   Order a copy of this article
    by Ashok Dwivedi 
    Abstract: Recombination influences the evolution of Saccharomyces Cerevisiae. Genomic regions where recombinations occurs are known as recombination hotspots. There are two kind of hotspots for recombination. The spots where recombination occurs more frequently are called recombination hot spots and regions where recombination occurs less frequently are known as cold spots. In this work, we have formulated methods based on neural network models for the classification of these hot and cold recombination spots on the basis of compositional features of nucleotide sequences. These models were validated using tenfold cross validation technique. The classification accuracy of 83%, 82%, and 78 % were achieved using radial basis function neural network with genetic algorithm, radial basis function neural network and multilayer perceptorn models respectively. Moreover, the performance of these model were evaluated on differenct classification measurements. Furthermore, results indicate that redial basis function neural network with genetic algorithm gives best result.
    Keywords: : Artificial Neural Network; Radial Basis Function Neural Network; Genetic Algorithm; Multi-Layer Perceptron; Classification; Machine Learning; Evolution.

  • Analysis of salivary components as non-invasive biomarkers for monitoring chronic kidney disease   Order a copy of this article
    by Navaneeth Bhaskar, Suchetha M 
    Abstract: Saliva, a valuable source of biochemical information, is a potential diagnostic substance that helps to identify many diseases. Studies have revealed that saliva tests help identify many diseases. Saliva test has excellent advantages over blood test as the former can be collected non-invasively using simple equipment. This paper explores how salivary components can be used as diagnostic tool to identify chronic kidney disease (CKD). Experimental analysis was conducted to assess the levels of salivary components in whole saliva of CKD patients in contrast with healthy people. Urea and creatinine are the most accepted biomarkers of CKD. The correlation between creatinine and urea levels in human saliva and blood were analyzed. Unstimulated saliva flow rate and pH levels were also monitored in this study. The results obtained from this study give concrete evidence that there is a positive correlation between creatinine and urea levels in blood and saliva. From the derived regression line equations, serum urea and creatinine values can be predicted from salivary values. Receiver operating characteristics (ROC) performance analysis was performed and area under the curve (AUC) of 0.95 and 0.89 was obtained for salivary creatinine and urea.
    Keywords: saliva; non-invasive; electrolytes; urea; creatinine; chronic kidney disease.

  • Time-Frequency Analysis based Method for Application of Infant Cry Classification   Order a copy of this article
    by J. Saraswathy, M. Hariharan, Wan Khairunizam, J. Sarojini, Sazali Yaacob 
    Abstract: This paper proposes a new investigation of time-frequency (t-f) based signal processing technique using wavelet packet spectrum (wpspectrum) for classification of newborn cry signals. T-f approaches can analyze the non stationary signals comprehensively in joint t-f domain compared to the time or frequency domain techniques. This study was initialized with the extraction of a cluster of t-f features from the generated t-f matrix of recorded cry signals using wpspectrum by extending time-domain and frequency-domain features to the joint (t-f) domain. In accordance, conventional features such as Mel-frequency cepstral coefficients (MFCCs) and Linear prediction coefficients (LPCs) were also extracted in order to compare the performance of the suggested t-f approach. Probabilistic neural network (PNN) and general regression neural network (GRNN) were used to evaluate the efficacy of the extracted feature vectors. The proposed methodology was implemented to classify different sets of infant cry signals cry including binary and multiclass problems. Best empirical result of above 99 % was reported and revealed the good potential of t-f methods in context of infant cry classification.
    Keywords: Keywords: Infant cry; Time-frequency analysis; Feature extraction; Classification.

  • Improving ECG Signal Denoising using Wavelet Transform for the Prediction of Malignant Arrhythmias   Order a copy of this article
    by Agostino Giorgio, Cataldo Guaragnella, Domenico Andrea Giliberti 
    Abstract: Objective: This paper deals with the accuracy of algorithms for the detection of cardiac Ventricular Late Potentials (VLP). The presence of VLP in an electrocardiographic signal (ECG) is associated with possible sudden cardiac death, because of malignant arrhythmias. VLP detection is strongly influenced by signal noise, thus the ECG needs to be denoised before VLP detection. The objective of this paper is to define a denoising algorithm improving the VLPs detection in ECG signal, and to describe its hardware implementation on a Field Programmable Gate Array device (FPGA). Methods: The method described uses wavelet denoising, implemented as subband coding. The drawbacks of this method are heavy linear distortions undergone by the analyzed signal. This disadvantage is overcome by using an equalization filter properly designed by the authors for canceling the introduced distortions. Results: The algorithm (equalizer filter + wavelet denoising) has been firstly implemented and successfully verified using MATLAB. Then, it has been implemented as programmable hardware on Alteras FPGA. The synthesized hardware has been verified on the evaluation board DE1-SoC, mounting a Cyclone V 5CSEMA5F31C6 FPGA chip. Conclusions: On board processed results and theoretical results are consistent, validating the effectiveness of the algorithm and of the designed hardware. Significance: Results show that the algorithm accuracy and its capability to be implemented as programmable hardware also could be used for upgrading ECG devices reliability in the field of heart diseases prevention.
    Keywords: Wavelet Transforms; Signal Detection; Biomedical Electronics; Denoising; FPGA.

  • Malignant Melanoma Detection using Multi Layer Preceptron with Visually Imperceptible Features and PCA Components from MED-NODE Dataset   Order a copy of this article
    by Soumen Mukherjee, Arunabha Adhikari, Madhusudan Roy 
    Abstract: In this paper, a scheme is worked out for classification of images belonging to malignant melanoma and nevus class by multi layer neural network architecture with different trainings and cost functions. Total 1875 shape, colour and texture features are extracted from 170 images from MED-NODE dataset. With the total 1875 features an accuracy of 82.05% is achieved. Feature ranking algorithm ReliefF is used for ranking these features. MLP is run with varying number of best ranked features. With 10 best features an accuracy of 83.33%, sensitivity of 86.77% and specificity of 72.78% are achieved with 3 fold cross-validation. Effect of pre-processing the features with Principal Component Analysis is explored and found that the optimal number of principal components is 25, which yields a maximum accuracy of 87.18% which is much higher than the previously reported accuracy level with this dataset.
    Keywords: ABCD rule; GLCM; GLRLM; ReliefF; Principal Component Analysis; Autocorrelation; Cross Entropy; t-test.

  • A REVIEW ON AUTOMATIC IDENTIFICATION OF FOVEA IN RETINAL FUNDUS IMAGES   Order a copy of this article
    by Rajesh I S, Bharathi M A, Bharati M. Reshmi 
    Abstract: Identification of retinal diseases is a very significant area of ophthalmology. Regular procedures are extremely specific, which rely on manual observation and highly prone to error. Hence, it is extremely fundamental to set up an automatic system for screening of vision-threatening diseases like Diabetic Retinopathy (DR) and Diabetic Maculopathy (DM). Patients who are suffering from DR are at high risk to have DM which may lead to blindness, if not detected and treated appropriately at the appropriate time. Automatic analysis of retinal images requires knowledge and the properties of anatomical structures and retinal lesions. Thus, locating fovea plays a vital role in the analysis of retinal images. In recent times image processing has become a very effective tool for the detection and analysis of abnormalities in retinal images. This survey paper depicts the fundamental terminology related to automatic detection of macula and fovea. The literature review of various methods used for finding fovea in retinal fundus images is discussed. Detection issues involved in fovea are also discussed in this paper.
    Keywords: Diabetic Retinopathy (DR); Diabetic Maculopathy (DM); Optic Disc (OD); Region of Interest (ROI); Blood Vessels (BVs).

  • Enhancement and segmentation of histopathological images of cancer using dynamic stochastic resonance   Order a copy of this article
    by Anuranjeeta Anuranjeeta, Munendra Singh, K.K. Shukla, Neeraj Sharma, Shiru Sharma 
    Abstract: Pathologists face difficulty in cell image detection as uneven dye causes the low contrast and inhomogeneity. The proposed Discrete Cosine Transform (DCT) based Dynamic Stochastic Resonance (DSR) technique enhances the histopathological images of cancer. Further, the DSR based Otsus thresholding processed image helps in the better segmentation of histopathological images of four types of cancer cells, i.e. breast, cervix, ovarian and prostate cancer. The comparison of segmentation results were performed on the University of California, Santabarbara (UCSB) available breast cancer datasets for analysis. The algorithm has been applied to total twenty-two (22) breast cancer images including benign and malignant and compared with Region of Interest (ROI) segmented Ground Truth images to validate the performance of proposed DSR based Otsus thresholding. DSR based Otsus segmentation obtained better results with 0.776 average correlation, 0.979 average normalized probabilistic rand (NPR) index, 0.011 average global consistency error (GCE), and 0.185 average variation of information (VI). These indices are higher than the other conventional segmentation methods and have the advantage to identify the target objects in low contrast images.
    Keywords: dynamic stochastic resonance; image enhancement; tissue; segmentation; histopathological image.

  • A Decision Support Tool Development: An Analysis of the Statistical Significance of the Dichotic Listening of Speech Test Results   Order a copy of this article
    by Elena A. Popova, Evgeny L. Wasserman, Nikolay K. Kartashev 
    Abstract: In this study, we analyze the statistical significance of the dichotic listening test results using two methods. The first method is based on the Agresti-Coull interval, and the other one is based on the sequential Wald analysis. We also propose a way to estimate the guaranteed boundaries for the eventual laterality index at every step of the dichotic listening test using the random walk method. This work is based on the analysis of 87 dichotic listening protocols of 59 children and adolescents of 416 years of age (patients of children's psychoneurological clinic) and three healthy adult volunteers. The dichotic listening was carried out in the clinical and laboratory conditions.
    Keywords: dichotic listening; speech; laterality index; random walk; lateralization; sequential Wald analysis; Agresti-Coull interval; decision support tool; statistical significance.

  • A Semantic Interoperability Framework for Distributed Electronic Health Record Based on Fuzzy Ontology   Order a copy of this article
    by Mohammed Elmogy, Ebtsam Adel, Shaker El-Sappagh, Sherif Barakat 
    Abstract: To achieve an efficient healthcare process; the professionals and doctors need to access the complete data about their patients in the suitable time. In the face of that issue; the medical data by natural is distributed across different systems and heterogeneous sources. From another angle; Healthcare semantic interoperability is still a huge problem without solving. In this paper, a unified semantic interoperability framework for distributed EHR based on fuzzy ontology is proposed. It consists of three main layers. The lowest layer (local ontologies construction) stores the EHRs heterogeneous data with different database schemas, standards, terminologies, purposes, locations, and formats. In the middle layer (global ontology construction) the local ontologies are mapped (using mapping algorithms or human experts with the help of common terminology vocabularies) to a global crisp one. The global reference ontology combines and integrates all local ontologies and therefore describes all data. Finally, the third layer is the user interface, in which a doctor can ask any linguistic or semantic queries by dealing with only the global reference fuzzy ontology. We expect that our framework will handle the current EHR semantic interoperability challenges, reduce the cost of the integration process, and get a higher acceptance and accuracy rate than previous studies.
    Keywords: Semantic Interoperability; Fuzzy Ontology; Unified data model; DB2OWL; X2OWL.

  • Changes in scale-invariance property of electrocardiogram as a predictor of hypertension   Order a copy of this article
    by HELEN MARY M C, Dilbag Singh, K.K. Deepak 
    Abstract: In this study, electrocardiogram signal has been investigated to assess the presence of scale-invariance changes to classify normotensive and hypertensive subject. ECG signal of 20 normotensive and 20 hypertensive subjects is recorded using MP100 system with a sampling rate (f_s) of 500 Hz. The scale-invariance changes of ECG signal are analyzed using multifractal detrended fluctuation analysis. The width and shape of the multifractal spectrum obtained is used to detect the hypertensive subject. The multifractal spectrum of the normotensive subject exhibit a pure Gaussian behavior, but for hypertension subject is left truncated. The width of the multifractal spectrum for hypertension subject (1.7158
    Keywords: Scale-invariance; Electrocardiogram; Multifractal spectrum; Hypertension.

  • Modified Model for Cancer Treatment   Order a copy of this article
    by Mahdi Rezapour Shafigh 
    Abstract: This paper proposes an optimal method for eradicating cancer, such that it cannot be relapsed. The major issue is that from the dynamical point of view, the tumor free equilibrium point at the end of chemotherapy is still unstable. Mathematically it means that when the chemotherapy is stoped, the dynamic behavior of the system moves away from the tumor free equilibrium point and the tumor cells starts increasing. To overcome this problem, we can either restart the process of chemotherapy or we try to stabilize the equilibrium point. In this paper the stabilization of the equilibrium point is proposed by applying a combination of vaccine therapy and chemotherapy method. According to this method, the vaccine therapy changes the dynamics of the system around the tumor free equilibrium point, and the chemotherapy pushes the system to the domain of attraction of the desired point. A suboptimal control strategy based on the State Dependent Riccati Equation (SDRE) is used for the chemotherapy process in this nonlinear cancer model. According to this method it is possible to study the particular conditions of an individual patient by choosing proper weighting matrices in the cost functions and limiting the dose of chemotherapy drug. It is shown, that, according to the simulation results, after completing the chemotherapy process, the dynamic of the system becomes stable and the cancerous cells converges to zero.
    Keywords: Cancer; Chemotherapy; Lyapunov stability; Mathematical model; SDRE control; Vaccine therapy.

  • ASSESSMENT OF DRUG DRUG INTERACTIONS AND ITS ASSOCIATED FACTORS IN PATIENTS RECEIVING SECOND-LINE ANTITUBERCULAR DRUGS (MDR TB/XDR TB) IN A TERTIARY CARE HOSPITAL IN EASTERN INDIA   Order a copy of this article
    by P.Ansuman Abhisek, Priti Das, Geetanjali Panda, Shweta Supriya Pradhan, Srikanta Mohanty 
    Abstract: In this paper, prevalence of drug-drug interactions (DDIs) in patients receiving second-line antitubercular drugs, their frequency, severity are assessed and possible mechanisms are analysed by applying different drug and clinical information software. This was a prospective, observational study conducted from January 2016 to June 2016 in Dept. of Pharmacology in collaboration with Dept. of Pulmonary Medicine, Sriram Chandra Bhanja Medical college and Hospital (SCBMCH), Cuttack, Odisha,India. by analyzing the prescriptions of 42 patients receiving second-line antitubercular drugs. DDIs were analyzed by using trial versions of software like lexicomp, micromedex and online free software like drugs.com, medscape.com drug interaction checker. Only interactions of major / moderate severity were included in the potential DDIs analysis. Descriptive analysis was performed using frequencies for categorical variables and mean, median, standard deviation as well as variance for quantitative variables. Quantitative assessments regarding number of interactions per software were compared using one way ANOVA. Qualitative assessment of software was done manually by mere observation of compilation of DDIs in Microsoft excel. Mean age of all the patients was 33.11 (SD=11.05) years. Patients received 12.52 (SD=
    Keywords: Prevalence; Frecuency; Severity; Risk; Pharmacodynamic; Micromedex; Lexicomp; Drugs.com; Medscape.

  • Peak alpha Neurofeedback training on Cognitive performance in elderly subjects   Order a copy of this article
    by Sofia Bobby 
    Abstract: slowing down of thought, memory and thinking is a normal part of aging. Mental exercise can help the brain to stay sharp. The EEG signal was acquired using single channel electrode from the occipital lobe, amplified using EEG amplifier and connected to the system through Data Acquisition Device (DAQ). The peak alpha band (10-11Hz) signal was extracted using LabVIEW software. The NFT protocol that was designed presented the neurofeedback training and thereby showed some improvement in their cognitive processing speed. The brain wave frequency was measured and analyzed in the course of training and the subject gradually learnt to stay in the desired brain wave state. The visual cues were fed to the LabVIEW software by making the subject visualize some animation or hear some audios. Twenty subjects aged between 60 and 65 were considered for this training. This study had investigated whether the training given to the elderly people showed improvement in the cognitive processing speed of their brain activity.
    Keywords: Electroencephalography (EEG); Peak Alpha; Neurofeedback training; labVIEW.

  • Predicting Oral Squamous Cell Carcinoma in Tobacco Users by utilizing Fuzzy based Decision Tree Algorithm   Order a copy of this article
    by Vasantha Kavitha, Hanumanthappa M 
    Abstract: Oral squamous cell carcinoma (OSCC) is one of the major type of malignant and its significant percentage is responsible for the common causes of death worldwide. Many people in India have the habit of smoking tobacco and consumption of alcohol which finally leads to OSCC. Diagnosis, prediction and control of the OSCC are traditionally based on the clinical signs, historical highlights and biomarkers. In dental hospital, patient may feel inconvenient for the diagnosis on the whole ordinary methods like physical exams. The patients need differential diagnosis biopsy to predict the Oral squamous cell carcinoma. In our research, our primary goal is to predict the OSCC from the efficient decision making methods to predict the cancer from the hybrid algorithm; fuzzy based decision tree algorithm. The entire process is experimented in Hadoop framework with the mapreduce programming model. The proposed system achieves 90% accuracy in the predictions of the oral cancer.
    Keywords: OSCC; decision tree; fuzzy logic; hadoop; mapreduce programming; classification.

  • A Frugal and Innovative Telemedicine Approach for Rural India- Automated Doctor Machine   Order a copy of this article
    by Aswath G.I., Shriram KV, Nalini Sampath 
    Abstract: Rural India is very poor [Disconnected] when compared to urban. Most of the developments have not yet reached rural India and most importantly, in Healthcare, it lacks good hospitals and sometimes they even don't have a good dispensary. Even when there are hospitals, rural people never get experienced Doctors. We know that rural people are more affected by many challenging diseases every year. To compensate all these problems and to provide a good health care even in rural villages we introduce an Automated Doctor Machine. This machine can be installed easily anywhere and also include all the required input sensors inbuilt to check the condition of the patient and also provide a diagnosis report with medicines. The patient's health report is updated to the health record in his cloud account once he receives the medicine. So, when he meets the doctor in future, the doctor can easily get his up to date health record and can also use the web app to update his health record. This is all frugal, cost-effective and fault tolerant.
    Keywords: Healthcare for Rural India; Telemetry Healthcare; IOT Medical kit; Automated Doctor Machine; Affordable Healthcare;.

  • LUNG CANCER CLASSIFICATION USING FEED FORWARD BACK PROPAGATION NEURAL NETWORK FOR CT IMAGES   Order a copy of this article
    by Pankaj Nanglia 
    Abstract: Manual computation of Lung Cancer is a time taking process. In the medical industry, Software Aided Detection (SAD) aims to optimize the classification process. This paper proposes Lung Cancer Detection for computed tomography (CT) images. It uses Speed up robust feature (SURF) for feature extraction, Genetic Algorithm (GA) for feature optimization and Feed Forward Back Propagation (FFBP), Neural Network (NN) for classification. The training mechanism utilizes 200 cancerous images and the proposed method results in 96% classification accuracy and 94.7% sensitivity. This paper also discusses the possible future modifications in the presented work.ork.
    Keywords: SAD; SURF; GA; FBPNN.

  • Study of murmurs and their impact on the heart variability   Order a copy of this article
    by Mokkedem Fatima, Meziani Fadia, Debbal Sidi Mohammed El Amine 
    Abstract: The phonocardiogram (PCG) signal processing approach seems to be very revealing for the diagnosis of pathologies affecting the activity of the heart. The aim of this paper is the application of an algorithm to explore heart sounds with simplicity in order to provide statistical parameters to better understand the cardiac activity by the calculation of the cardiac frequency and examine the impact of minor and pronounced murmurs on the cardiac variability. This paper conduct to clarify the variation of the cardiac frequency affected by several groups of murmurs and investigate the medical reasons behind the obtained results. A high number of cycles was used to better refine the expected results.
    Keywords: cardiac variability; cardiac frequency; phonocardiogram signal; murmur; click; detection; duration.

  • Dietary Macro-nutrients Intake And Risk Of Obesity & Type II Diabetes: To compute a model to predict probability of developing Hypertrophic Obesity and Type II Diabetes based on the macro-nutrient intake levels.   Order a copy of this article
    by Shalini Pattabiraman, Riddhi Vyas, Shankar Srinivasan 
    Abstract: Good nutrition and healthy diet are the primary pre-requisites for a healthy and balanced lifestyle. Improper proportions of dietary macronutrients in the food lead to implicated risk of chronic diseases. Energy consumption and energy expenditure should be balanced in order to maintain the body mass and to avoid the complication resulting from excess body weight. Obesity is the global cause of many chronic diseases, which is why diet has an important role towards the risk of incidence of chronic diseases such as diabetes, high blood pressure and cardiovascular diseases. The purpose of this study is to compute a model to predict the risk for obesity and diabetes based on the macro-nutrient intake levels (High/Low). The SAS (Statistical Analysis Software) datasets from NHANES (2013-14) were extracted, then using descriptive statistical analysis (chi-sq & Pearsons correlation) and logistic regression analysis in SAS, a model is computed for each disease with significant predictive macro-nutrient intake variables. An ROC (Receiver Operating Characteristic) curve and predicted probability plots were analyzed for the accuracy of the model. It was found that the significant predictor variables identified for each disease risk corroborates with the literature studies, but further studies may be required with normalization of the data in order to validate the results of this study.
    Keywords: Obesity; Type II Diabetes; dietary intake; macro-nutrients; prediction model; NHANES; National Health and Nutrition Examination Survey; SAS; Statistical Analysis Software; ROC; Receiver Operating Characteristics; descriptive statistical analysis; predictor variables.

  • A Framework for Disease Diagnosis Based on Fuzzy Semantic Ontology Approach   Order a copy of this article
    by Nora Shoaip, Shaker El-Sappagh, Sherif Barakat, Mohammed Elmogy 
    Abstract: In this paper, we propose an OWL2 ontology based on SNOMED CT standard medical terminology. It can provide significant help to support physicians in diabetes risk level diagnosis problem. It explicitly defines the semantics of diabetes knowledge by using ontology and deal with the imprecise and vague nature of its data by using fuzzy set theory. It involves building a complete linguistic fuzzy rule-base that can integrate knowledge from expert and CPG with knowledge extracted from training data and knowledge extracted from the semantic model. This step enhances the level of automation and interoperability of CDSS. The importance of our work comes from the current lack of studies related to the integration of the formal integration between the ontology semantics and FES reasoning, especially in the medical domain. The ontology acts as an integral and complementary component of the FES.
    Keywords: Diabetes mellitus; clinical decision support system; fuzzy rule-based systems; semantic similarity; ontology reasoning.

  • A novel method of Cardiac Arrhythmia detection in ECG (Electrocardiogram) signal   Order a copy of this article
    by VARUN GUPTA 
    Abstract: ECG (Electrocardiogram) is an essential approach for observing the right condition of the heart. Generally, it represents P, Q, R, S, T and U waves. On the basis of these waves doctors can accurately diagnose cardiac arrhythmias. ECG signal is non-linear in nature and due to this, its analysis becomes very much complex and needs extra attention towards its analysis.A more reliable and accurate technique is needed for saving the life of the heart patients. So chaos theory applied to different ECG databases. R-peak is very crucial for classifying cardiac arrhythmia. For detecting R-peaks, STFT have been used and their frequency contents. In this paper physionet database has been tested.
    Keywords: ECG (Electrocardiogram); cardiac arrhythmia; non-linear; Chaos theory; R-peaks.

  • Non-Spectral Features based Robust Speaker Independent Emotion Recognition from Speech Signal   Order a copy of this article
    by Revathi Dhanabal, Lakshmi Chelliah, Thenmozhi Karruppusami 
    Abstract: To ensure the better and effective human-machine interaction, affective computing is playing a vital role in the current scenario Since speech and glottal signals convey the information about the emotional state of the speaker in addition to the linguistic information, it is very important to recognize speakers emotions and respond to it in expressive manner This paper mainly discusses the effectiveness of non-spectral features and modeling techniques to develop the robust multi speaker independent speakers emotion/stress recognition system Since, EMO-DB Berlin database and SAVEE emotional audio-visual database used in this work contain only limited set of speech utterances uttered by ten/four actors/speakers in different emotions, it has become a challenging task to improve the performance of the stress recognition system This algorithm provides 81%and 100% as weighted accuracy recall for the stress recognition system Weighted accuracy recall is found to be 100% for the classification done on emotion specific group.
    Keywords: Emotion recognition system (ERS); Vector quantization (VQ); Energy; Loudness; Zero crossing rate; Fundamental frequency; Fuzzy C means clustering (FCM); Minimum distance classifier.

  • A Comparative Study for Improved Hospital based Cancer Registry for Early Stage Prediction of Breast Cancer with Highest Accuracy   Order a copy of this article
    by Smita Jhajharia 
    Abstract: Breast cancer prediction has always been a challenge and machine-learning algorithms provide great assistance in this regard. This research paper precisely reports efforts in identification and development of appropriate algorithms that can predict breast cancer with high accuracy. The research undertaken is based on rigorous analysis of data collected from Bikaner, Rajasthan, India and its quality and features in comparison to the standard SEER dataset. The results confirm the applicability of classification algorithms like Support Vector Machine in building a machine-learning model for accurate prediction of early stage breast cancer. Finally, as a highlighting contribution, a prediction model, which resulted in prediction of cancer with 99% accuracy on the data collected from Patients in Bikaner, Rajasthan, India has been presented. This model will help to improve the National Cancer Registry Program and Hospital based cancer registry systems.
    Keywords: National Breast Cancer Registry; SEER Data; Breast Cancer analysis using R.

Special Issue on: Health Engineering and Informatics

  • Bio-Medical Analysis of Breast Cancer Risk Detection based on Deep Neural Network   Order a copy of this article
    by Nivaashini M, Soundariya R S 
    Abstract: - Breast tumor remains a most important reason of cancer fatality among women globally and the pathetic condition is that most of them pass away due to delayed diagnosis. But premature recognition and anticipation can significantly diminish the chances of death. Risk detection of breast cancer is one of the major research areas in bioinformatics. Bioinformatics can be narrowly defined as a field at the crossroads of biology and computer engineering, responsible for the storage, distribution, and analysis of biological information. Various experiments have been conceded to examine the fundamental grounds of breast tumor. Alternatively, it has already been verified that early diagnosis of tumor can give the longer survival chance to a patient. Consequently, early prediction of breast tumor is very critical to rescue a patients life. To deal with this issue, in the proposed framework a model with deep learning techniques has been introduced to identify breast tumor at primary stage. This paper aims at finding an efficient set of features for breast tumor prediction using deep learning approaches called Restricted Boltzmann Machine (RBM). The proposed framework diagnoses and analyzes breast tumor patients data with the help of Deep Neural Network (DNN) classifier using the Wisconsin dataset of UCI machine learning Repository. and, thereafter assesses their performance in terms of measures like Accuracy, Precision, Recall, F-Measure, etc.
    Keywords: Breast tumor Prediction; Feature Selection; Restricted Boltzmann Machine; Deep Neural Network.

  • A REVIEW ON EMOTION RECOGNITION IN PARKINSONS DISEASE USING BIOINFORMATICS   Order a copy of this article
    by Rejith K.N., Kamalraj Subramaniam 
    Abstract: Parkinsons disease individuals have been stressed and shown difficulty in emotion recognition & facial expression with increasing cognitive decline. In recent years, various studies have been conducted in emotion recognition of Parkinsons disease patients. In many research works, emotional state assessment using facial expression and EEG based stimuli were used for emotion recognition study. In this paper, a review of EEG based emotion recognition in Parkinsons disease and its various research analyses in the past two decades have been analyzed. Most of the papers have investigated total of six emotions in Parkinsons disease study such as happiness, sadness, fear, anger, surprise, and disgust to evaluate the emotion difficulties in Parkinsons disease people.
    Keywords: Cognitive deficit;Electroencephalogram;Emotion; Emotional deficits; Event related potencial;Facial emotion recognition; Non-linear methods; Parkinson’s disease.

  • QUERY OPTIMIZATION WITH WEIGHTED FISH SCHOOL SEARCH IN ONTOLOGICAL DATABASE WITH APPLICATION OF BOINFORMATICS   Order a copy of this article
    by Jaya Raju 
    Abstract: Making queries from large ontological database has a severe problem of generating query plans as it is made in form of left tree search form. This restricts the querying for composite applications and speed of acquiring query results. In such a scenario the most prominent approach is to optimize the indexing of graph nodes in ontological database and many evolutionary and particle of swarm optimization (PSO) based approach had already been attempted. However, loss of diversity and unanticipated convergence causes the solution to remain sub-optimal. In this study we present a weighted fish school searching based query optimization technique owing to its scalability and self control functioning with the application of bioinformatics. It creates probabilistic logic based weight system for the fish school search in a hierarchical tree form which results in increased accuracy when put in comparison with standard PSO based methods and its other variants
    Keywords: optimization; semantic data; PSO.

  • A cloud based secured Framework for smart Medical Diagnosis: A Survey   Order a copy of this article
    by Leelavathy Mrs, Selva Brunda S 
    Abstract: Enormous amounts of medical data are being collected by several well-developed HIS (Hospital Information Systems) in the form of patient records in hospitals. The hidden patterns and relationships contained in this data are identified using various data mining techniques which has drawn increasing world-wide attention in the recent years. As a result of which, a good number of MDSS (Medical Decision Support Systems) have been developed. These are computer systems designed to assist physicians or other healthcare professionals in making clinical decisions for the given patients symptoms and medical history. Inspired by the existing systems, the model proposed in this paper aims at making a knowledge sharing collaborative platform for doctors which serves as a realistic and effective Medical Decision Support System. It is important because it provides vital information from different data sources. It has several challenges like scalability, response time , heterogeneous data formats . This paper does a detailed study of different challenges in understanding about medical information that can be provided to users in a better manner . A framework named Intelligent Health care Framework(ISHF) is being proposed in this paper.
    Keywords: Medical decision support system (MDSS); Bioinformatics; diagnosis; knowledge discovery and symptoms.

  • A Study on Indirect Immunofluorescence Image Classification Methods for Bioinformatics   Order a copy of this article
    by Divya BS, Kamalraj Subramaniam, Nanjundaswamy HR 
    Abstract: The Indirect Immunofluorescence (IIF) test with Human Epithelial type-2 (HEp-2) cells as substrates is the gold standard for Anti Nuclear Antibodies (ANA) test to diagnose autoimmune diseases. The specialists in the laboratory visually examine the specimen under microscope to recognize the staining patterns and generate the report. So ANA test is subjective and needs systemic automation for bioinformatics. In this view international benchmarking initiatives were organized by IAPR in the last six years. In this paper the state of the art on IIF HEp-2 cells classification task was analyzed. This paper highlighted the original aspects with the detailed discussion of the published methods. Design choice verses performance was analyzed.
    Keywords: Anti Nuclear Antibodies; pattern classification; HEp-2 cell,Computer Aided Diagnosis; Indirect Immunofluorescence; Healthcare System.

Special Issue on: Biomedicine in Industry and Society

  • ALLIUM SATIVUM - BREAST CANCER THERAPEUTIC AGENT TO REPLACE ALLOPATHIC TREATMENTS WITH EXTENSIVE SIDE - EFFECTS   Order a copy of this article
    by Neha Vutakuri, Sita Somara 
    Abstract: Cancer is a life-threatening disease that can grow in any part of the human body and may result in the abnormal growth of millions to trillions of cells. There are currently 200 types of human cancers. Cancer is treated with various treatments, such as surgery, radiation therapy, chemotherapy, immunotherapy, stem cell transplantation, targeted therapy, and others. However, these treatments produce side effects, such as anemia, diarrhea, appetite loss, bleeding, hair loss, infections, lymphedema, nerve problems, urinary, bladder problems, and others. The side effects of cancer treatments may also lead to death. Some spices are used to naturally fight cancer. Spices are usually used in cooking as a flavoring ingredient and may have thousands of medicinal characteristics. Spices such as turmeric, ginger, garlic, saffron, black pepper, cayenne pepper, mustard, mint leaves, black cumin, and others are used in Ayurveda medicines for the natural treatment of cancer. This paper addresses the use of garlic (Allium sativum) in the treatment of breast cancer and its promising results. Garlic is a medicinal plant and an antibacterial agent that provides many benefits to humans if consumed in the regular diet. Garlic has been used for thousands of years to treat several diseases and is known to inhibit breast cancer growth. Many epidemiological studies have found that garlic is one a natural remedy that inhibits the growth of breast cancer cells. The dietary consumption of garlic in various forms effectively minimizes the growth of breast cancer and other diseases. This paper provides a complete description of garlic including its history and then discusses its utility for preventing of breast cancer and its use in clinical trials; hence, this paper will be helpful for researchers and physicians in treating breast cancer.
    Keywords: Breast cancer; Spices treatment; Garlic; Ayurveda; Antibacterial agent.

  • Investigation of Problems faced during capturing of Gait Signals   Order a copy of this article
    by Vinothkanna Rajendran, Prabakaran Narayanaswamy, Sivakannan Sivakannan 
    Abstract: To solve the issue of close human contact in biometric authentication system, relatively a new technique gait recognition is used. The human gait is a common feature for identifying the walking manner of the person during walking and it is viewed as significant indicator for gait function of individual for experimental and research setting. Gait symmetry is usually considered as function of locomotion between the changes of the body and its activities. An exclusive advantage of gait as a biometric is its latent for detection at a distance or at low resolution or when other biometrics might not be perceivable. In this paper we investigate the problem of people recognition by their gait. The coordination and cyclic nature of the body motion makes gait as unique characteristics of each individual, thus a good biometric identification approach. The purpose of this paper is to describe some of the problems that make it difficult to apply gait as a biometric identification and use recent literature to show suggestions being made to solve some of these technical issues.
    Keywords: Gait recognition; biometrics; walking style; pathology; injuries.
    DOI: 10.1504/IJMEI.2020.10015912
     
  • Improving the Classifier accuracy with an Integrated approach using Medical data - A Study   Order a copy of this article
    by Maragatham Ganesan, Rajendran S 
    Abstract: As information plays a vital role in the current scenario, Fetching of information from the voluminous quantity seems to be challenging. Therefore, the data mining community work on this area to find an improved solutions to help the end users. The end users may be an organization or may be an ordinary user. The authors have used different classification techniques for the study purpose. The article attempts to analyze the accuracy of classifiers with respect to that of medical data. Dataset from the repository is considered for analyzing purpose. Initially a preprocessing step is used on the data set for finding out the missing values. Next, the resulting data set is applied to the classifiers to study its performance accuracy. Initially, after the preprocessing step a classifier is selected based on which the accuracy of the classifier is studied. Next, a subset evaluation step is performed to determine the relevant attributes. In order to improve the classifier accuracy an attribute selection filter of supervised category is selected. In this article, the authors have done a study on integrated approaches that helps in classifying the instances of a bio-medical data. For the analysis purpose the Na
    Keywords: Naive Bayes; Multilayer perceptron; chi-square; logistic regression.

  • Wavelet Packet Transform based Medical Image Multiple Watermarking with Independent Component Analysis Extraction   Order a copy of this article
    by Nanmaran Rajendiran, Thirugnanam Gurunathan, Mangaiyarkarasi Palanivel 
    Abstract: Rapid growth of internet in all aspects of life has led to the easy availability of the digital data to everyone. E-commerce, telemedicine etc., are among the many applications of internet. Telemedicine is a crucial field where internet finds application. Healthcare professionals use internet to transmit and receive medical data. Thus the medical images can be shared, processed and transmitted through computer networks. All patient records, linked to the medical secrecy, must be confidential. Because of the importance of the security issues in the management of medical information, there is a need to develop watermarking techniques for protecting medical images. In this paper, colour medical image watermarking methods rely on Wavelet Packet Transform (WPT) and extraction using Independent Component Analysis (ICA). For watermark extraction, Pearson ICA is applied as it attains the new trait is that it not entail the renovation procedure in watermark extraction. The grades show that projected method is vigorous beside attacks such as Gaussian noise, Salt and Pepper noise, Rotation and Translation. The performance measures like PSNR, Similarity Measure and Normalized Correlation are assessed to confirm the robustness of the scheme.
    Keywords: discrete wavelet transform; image watermarking; independent component analysis; pearson ICA; wavelet packet transform.rn.

  • Novel feature extraction of EEG signal for accurate event detection   Order a copy of this article
    by S. Saravanan, S. Govindarajan 
    Abstract: Electroencephalograph (EEG) signal analysis is one of the essential for diagnosis of diseases, detect the various event and psychological problems. The accuracy of event detection depends on the feature vectors used. The feature vectors in literature provide performance only for a specific application and perform poor for other application. This paper presents a new feature vector generation using fusion of energy feature vectors of different types. The energy features of alpha, beta and gamma component is extracted as base feature. A fusion rule is formulated to fuse that base features using Hjorth activity features to improve the accuracy of classification. The performance of the proposed new feature is tested on seizures detection, sleep state detection and emotion detection application. The resulting analysis shows that the proposed new feature outperform with improved accuracy of 26% for emotion detection, 5% for seizures detection and 4% for sleep state detection.
    Keywords: electroencephalograph; EEG; event detection; energy feature; emotion detection; feature extraction; fusion; Hjorth activity; seizures detection; sleep state detection.
    DOI: 10.1504/IJMEI.2020.10016037
     
  • An Amalgamated Prediction Model for Breast Cancer Detection using Fuzzy Features   Order a copy of this article
    by Smita Jhajharia 
    Abstract: Machine learning techniques for cancer prognosis are being widely researched and applied. Supervised learning in conjunction with other computational techniques are paving the way forward for predictive health analytics. The step of input feature processing is very important in order to obtain meaningful results from a data analytics problem. In this paper, the Extended Kalman Filter (EKF) and Fuzzy K-Means clustering algorithms have been combined and a hybrid algorithm is proposed with improved functionality compared to either of the two separately. The proposed hybrid algorithm implements a fuzzy K-means algorithm with Support Vector Machine (SVM)coupled with an EKF for data filtering. From the filtering and prediction consecutive cycles, the result of Kalman filters is obtained and fuzzy membership functions are calculated in order to form a relationship between the labels and attributes. K-means utilizes this relationship to create a new modified set of attributes, which are given to the SVM classifier, with lesser number of support vectors. The number of clusters is added into the training process as the input parameter except the kernel parameters and the SVM penalty factor. The approach was tested for various publicly available data sets like UCL,SEER and a real data set compiled by the authors. After performing statistical analysis, the accuracy, precision, recall and F-score value of the algorithm have been found and compared against those obtained from the traditional algorithms.
    Keywords: Cancer; Clustering; Extended Kalman Filter; Fuzzy K-Means.

  • OPTIMIZED FEATURE SELECTION AND ENTROPY-BASED GRAPH CLASSIFICATION OF GENE EXPRESSION DATA   Order a copy of this article
    by Audu Musa Mabu, Rajesh Prasad, Raghav Yadav 
    Abstract: Purpose: Gene expression (GE) profiles expansively revised to disclose intuition into the multifariousness of cancer furthermore to discover concealed information which provides biological knowledge for the classification of cancer. Precise cancer classification straightly through original GE profiles stays challenging on account of the intrinsic high-dimension feature along with the small magnitude of the data samples. Therefore, choosing high discriminative genes as of the GE data have turn into progressively fascinating in the bioinformatics field. This given paper gives a technique for the GE data classification utilizing entropy based graph classifier. Methodology: Initially, the proposed technique evaluate the GE datas SNR (Signal to Noise Ratio) values, additionally, selects the relevant features using KH (Krill Herd) optimization process. The truth is that not all features are helpful for classification, and some redundant together with the irrelevant features might even serve as outlier. To dispose the outliers, feature reduction is done with the assist of Euclidean distance. Classification is made utilizing entropy based graph classifier. Conclusion: The proposed process effectiveness contrasted with the existing method concerning classifications is established from the Experimental outcome.
    Keywords: Gene Expression Profile; Bioinformatics; Entropy; Graph Classifier; Krill Herd Optimization; Signal to Noise ratio.

  • Novel Multiphase Contouring and Force Calculation Algorithm for ROI Detection and Calculation of Energy value in Multiple Scale and Orientation for Early Detection of Stages of Breast Cancer   Order a copy of this article
    by Varalatchoumy M, Ravishankar M 
    Abstract: A Novel Multiphase Contouring and Force calculation (MCFC) algorithm has been developed to perform segmentation and detect Region of interest (ROI) in a very efficient manner in mammographic images. Detected malignant tumors were further processed using a novel approach in order to identify the stages of breast cancer (stage I or II) precisely. The whole process starts with the Preprocessing phase that aids in enhancement and noise removal of the input mammographic images. Preprocessed image is segmented using the MCFC algorithm to detect the ROI. This algorithm has aided in achieving robust segmentation at very low computation time. Combination of wavelet and textural features were used to train the Artificial Neural Network to classify the detected ROI as normal, benign or malignant tumor. Stages of the detected malignant tumors are identified using a very novel approach of calculating the energy values in four different scales and six orientations for each scale. A total of 24 energy values are used to train the Artificial Neural Network to detect the stages of the malignant tumor in a very precise manner. Overall system performance has been tested on 45 real time patients mammographic images obtained from hospitals. Detection of malignant tumor and its stages have been verified by experts in medical field. The overall accuracy of the novel algorithm and the staging approach if 97% for MIAS database images and 90% for real time mammographic images
    Keywords: Multiphase Contouring and Force calculation (MCFC); stages of breast cancer; wavelet and textural features; energy values.

  • EEG signal analysis and classification on P300 speller-based BCI performance in ALS patients   Order a copy of this article
    by Mridu Sahu, Shrish Verma, Naresh Kumar Nagwani, Sneha Shukla 
    Abstract: Objective: the objective of the presented work is to analyse the electroencephalography signal based on brain computer interface by using P300 speller for amyotrophic lateral sclerosis (ALS) patients and perform classification on extracted features to get accuracy. Analysis/methods: amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that involves the degeneration and death of nerve cell in the brain. It affects the process related to speech and loss of motor function in the patient. BCI technology is a communication solution for all amyotrophic lateral sclerosis (ALS) patients. The P300 speller included in the BNCI Horizon 2020 data is an application allows calculating the accuracy of classifier, which is necessary for the user to spell letters or sentences in a BCI speller paradigm. In this paper, we have extracted wavelet and power spectral density features. Association rule mining and ranking method is used for feature selection. For the classification, we have used multiple techniques and different classifiers and out of those, ten best techniques are selected based on their good performance. Finding: as a result, we get maximum 75% accuracy when we used random committee classifier.
    Keywords: amyotrophic lateral sclerosis; ALS; brain computer interface; BCI; electroencephalography; EEG; P300 speller; power spectral density; PSD; wavelet; association rule mining; ARM.