Title: Preparation of human serum albumin nanospheres labelled with ¹⁸⁸Re

Authors: Virginia Nazarica Borza, Elena Neacsu, Catalina Mihaela Barna, Nicoleta Popescu-Pogrion, Ionel Mercioniu, Cristina Lavinia Nistor

Addresses: 'Horia Hulubei' National Institute of R&D for Physics and Nuclear Engineering, IFIN-HH, 407 Atomistilor Street, Bucharest – Magurele, P.O. Box MG-6, code 077125, Romania. ' 'Horia Hulubei' National Institute of R&D for Physics and Nuclear Engineering, IFIN-HH, 407 Atomistilor Street, Bucharest – Magurele, P.O. Box MG-6, code 077125, Romania. ' 'Horia Hulubei' National Institute of R&D for Physics and Nuclear Engineering, IFIN-HH, 407 Atomistilor Street, Bucharest – Magurele, P.O. Box MG-6, code 077125, Romania. ' National Institute of Materials Physics, 105 bis Atomistilor Street, Bucharest-Magurele, P.O. Box MG-7, code 077125, Romania. ' National Institute of Materials Physics, 105 bis Atomistilor Street, Bucharest-Magurele, P.O. Box MG-7, code 077125, Romania.' National Research and Development Institute for Chemistry and Petrochemistry, ICECHIM 202 Independence Street, District 6, CP 35-174, 060021 Bucharest, Romania

Abstract: The aim of this paper is to present a method for the labelling human albumin nanospheres with the short lived beta emitter ¹⁸⁸Re. In this method stannous chloride is used as reducing agent and potassium sodium tartrate as transchelation agent. Optimal parameters of the labelling reaction and also, the stability of the radiolabelled nanospheres were established. Under optimal reaction condition, after 45 min. at 75°C, the labelling yields were more than 95%; also, 97% of the ¹⁸⁸Re is bound to the albumin nanospheres at 20 h after labelling.

Keywords: albumin nanospheres; labelling methods; 188Re; radiotherapy; endoradiotherapy; tumours; radiolabelling; beta emitters; drug delivery; nanoparticles.

DOI: 10.1504/IJNBM.2009.028343

International Journal of Nano and Biomaterials, 2009 Vol.2 No.6, pp.547 - 553

Published online: 16 Sep 2009 *

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