Preparation of human serum albumin nanospheres labelled with ¹⁸⁸Re
by Virginia Nazarica Borza, Elena Neacsu, Catalina Mihaela Barna, Nicoleta Popescu-Pogrion, Ionel Mercioniu, Cristina Lavinia Nistor
International Journal of Nano and Biomaterials (IJNBM), Vol. 2, No. 6, 2009

Abstract: The aim of this paper is to present a method for the labelling human albumin nanospheres with the short lived beta emitter ¹⁸⁸Re. In this method stannous chloride is used as reducing agent and potassium sodium tartrate as transchelation agent. Optimal parameters of the labelling reaction and also, the stability of the radiolabelled nanospheres were established. Under optimal reaction condition, after 45 min. at 75°C, the labelling yields were more than 95%; also, 97% of the ¹⁸⁸Re is bound to the albumin nanospheres at 20 h after labelling.

Online publication date: Wed, 16-Sep-2009

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