Label-free detection of biomaterials using terahertz technology
by Rafal Wilk, Felix Stewing, Frank Rutz, Thomas Kleine-Ostmann, Martin Koch
International Journal of Nanotechnology (IJNT), Vol. 2, No. 3, 2005

Abstract: We present terahertz (THz) absorption spectra of various biomolecules (tripeptide gly-gly-gly and oligo-nucleotides poly[A] and poly[C]). While the tripeptide shows unique resonances in the THz range due to intramolecular vibrations, the different oligo-nucleotides can be distinguished due to different absorption properties. In space-resolved THz free-space measurements, we were able to repeatedly distinguish between dried drops of poly[A] and poly[C]. In addition, we present the design for a new class of filters for on-chip analysis of biomaterials. As compared to filters described earlier in the literature, the new structures have an increased sensitivity and require much less biomaterial.

Online publication date: Fri, 11-Nov-2005

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