Nanocomposite materials with antimicrobial activity based on chitosan
by Mihaela D. Leonida; Sudeep Banjade; Thong Vo; Gloria Anderle; Gerhard J. Haas; Neena Philips
International Journal of Nano and Biomaterials (IJNBM), Vol. 3, No. 4, 2011

Abstract: Chitosan nanoparticles (CNP) were prepared by ionic gelation using sodium tripolyphosphate. Metal-enhanced CNP were prepared using the same procedure in the presence of Cu2+ and Ag+, respectively. The nanoparticulate materials were characterised by FTIR, SEM and antimicrobial assays. The CNP showed higher antimicrobial effect than chitosan against S. saprophyticus and E. coli. The effect did not seem to depend on the molecular weight of the starting chitosan. Cu2+ and Ag+, both known as antimicrobial agents, showed synergistic effects with chitosan against both organisms. The skin regenerative potential of CNP and metal-enhanced CNP was tested by assessing skin cell (fibroblast, keratinocyte) proliferation. The present study also suggests that chitosan and its nanoparticles inhibits MMP-1 expression in skin fibroblasts and keratinocytes, and may thereby inhibit skin aging and facilitate the ECM remodelling phase of wound healing.

Online publication date: Wed, 14-Mar-2012

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