Bioactive compounds obtained by immobilisation of serine protease inhibitors
by Mihaela Carmen Eremia; Irina Lupescu; Luminita Tcacenco
International Journal of Nano and Biomaterials (IJNBM), Vol. 3, No. 4, 2011

Abstract: We studied the preparation of polymeric membranes formed of solutions of poly-3-hydroxybutyrate (PHB) and chitosan. PHB-chitosan biomaterials from these solutions may form various structural types, which determine the biodegradation time, the adsorption capacity, and the kinetics of the release of medicinal compounds from polymeric matrices. Serine protease inhibitors, SERPINs, continue to catch the attention of researchers because of their increasing use in medicine and biotechnology. We prepared and studied the properties of biodegradable materials containing the serine protease inhibitors, soybean trypsin inhibitor (abbreviate STI) and watermelon (Citrullus vulgaris) trypsin inhibitor (abbreviate CVTI). Properties of bioactive compounds bound to the above mentioned polymers (proteolytic activity, porous structure, and increased hydrophilicity) account for their use in two key medical applications: drug delivery and tissue engineering.

Online publication date: Wed, 14-Mar-2012

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Nano and Biomaterials (IJNBM):
Login with your Inderscience username and password:

    Username:        Password:         

Forgotten your password?


Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com