Bioactive compounds obtained by immobilisation of serine protease inhibitors Online publication date: Fri, 28-Nov-2014
by Mihaela Carmen Eremia; Irina Lupescu; Luminita Tcacenco
International Journal of Nano and Biomaterials (IJNBM), Vol. 3, No. 4, 2011
Abstract: We studied the preparation of polymeric membranes formed of solutions of poly-3-hydroxybutyrate (PHB) and chitosan. PHB-chitosan biomaterials from these solutions may form various structural types, which determine the biodegradation time, the adsorption capacity, and the kinetics of the release of medicinal compounds from polymeric matrices. Serine protease inhibitors, SERPINs, continue to catch the attention of researchers because of their increasing use in medicine and biotechnology. We prepared and studied the properties of biodegradable materials containing the serine protease inhibitors, soybean trypsin inhibitor (abbreviate STI) and watermelon (Citrullus vulgaris) trypsin inhibitor (abbreviate CVTI). Properties of bioactive compounds bound to the above mentioned polymers (proteolytic activity, porous structure, and increased hydrophilicity) account for their use in two key medical applications: drug delivery and tissue engineering.
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