Molecular imaging with targeted quantum dot bioconjugates: the need for contrast optimisation studies
by Mathieu Roy, Brian C. Wilson
International Journal of Nanotechnology (IJNT), Vol. 6, No. 5/6, 2009

Abstract: Quantum dots have the potential to be used as contrast agents for molecular imaging in vivo, but there are many challenges in optimising such procedures, both in pre-clinical animal models and in the potential clinical applications. In particular, it is critical to obtain the optimal target-to-background contrast to achieve maximum diagnostic accuracy. However, available data are insufficient to determine the optimal parameters for this objective. Here, we explore the factors that affect imaging contrast with quantum dots, including time, dosage, emission and excitation wavelengths, and instrumentation. This includes a brief review of the published work. In addition, we present initial studies with tissue-simulating phantoms that allow the optimum excitation wavelength to be determined for visible-emitting quantum dots used to image surface or near-surface lesions, as found in endoscopic diagnosis of early cancer. We also suggest needed areas for future research for optimisation of quantum dot-based bio-imaging applications.

Online publication date: Mon, 13-Apr-2009

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Nanotechnology (IJNT):
Login with your Inderscience username and password:

    Username:        Password:         

Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email