Improving domain-based protein interaction prediction using biologically-significant negative dataset Online publication date: Thu, 07-Sep-2006
by Xiao-Li Li, Soon-Heng Tan, See-Kiong Ng
International Journal of Data Mining and Bioinformatics (IJDMB), Vol. 1, No. 2, 2006
Abstract: We propose a domain-based classification method to predict protein-protein interactions using probabilities of putative interacting domain pairs derived from both experimentally-determined interacting protein pairs and carefully-chosen non-interacting protein pairs. Multi-species comparative results for protein interaction prediction show that such careful generation of biologically-meaningful negative training data can improve classification performance.
Online publication date: Thu, 07-Sep-2006
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