Title: Optimisation of hydrothermal process for the fabrication of TiO2 nanowire matrix chip for laser desorption ionisation mass spectrometry

Authors: Mira Kim; Jong-Min Park; Joo-Yoon Noh; Jo-Il Kim; Min-Jung Kang; Jae-Chul Pyun

Addresses: Department of Materials Science and Engineering, Yonsei University, 50 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, South Korea ' Department of Materials Science and Engineering, Yonsei University, 50 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, South Korea ' Department of Materials Science and Engineering, Yonsei University, 50 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, South Korea ' Institute of Pharmaceutical and Medical Chemistry, University of Muenster, Muenster, 46321, Germany ' Korea Institute of Science and Technology (KIST), Seoul 02792, South Korea ' Department of Materials Science and Engineering, Yonsei University, 50 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, South Korea

Abstract: Recently, TiO2 nanowires synthesised from a Ti plate by the hydrothermal process have been used as a solid matrix for laser desorption/ionisation time-of-flight (LDI-TOF) mass spectrometry (MS). In this work, the influence of the surface condition of the Ti plate according to its level of polishing on the ionisation of samples in laser desorption/ionisation (LDI) MS has been estimated. The surface morphology and roughness were analysed with scanning electron microscopy (SEM) and atomic force microscopy (AFM), respectively. Subsequently, TiO2 nanowires synthesised from Ti plates polished to different levels were applied to LDI MS for the analysis of amino acids and the optimal surface condition of the Ti plate was estimated.

Keywords: TiO2 nanowire; hydrothermal; MALDI-TOF; matrix-assisted laser desorption/ionisation time-of-flight; LDI; laser desorption/ionisation; MS; mass spectrometry.

DOI: 10.1504/IJNT.2018.096350

International Journal of Nanotechnology, 2018 Vol.15 No.6/7, pp.598 - 610

Received: 08 May 2021
Accepted: 12 May 2021

Published online: 21 Nov 2018 *

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