Title: Thin membrane with biomimetic hexagonal patterned surface for guided bone regeneration

Authors: Anurag Satpathy; Rinkee Mohanty; Tapash Ranjan Rautray

Addresses: Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, 751030, Odisha, India ' Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, 751030, Odisha, India ' Biomaterials and Tissue Regeneration Lab, Centre of Excellence in Theoretical and Mathematical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, 751030, Odisha, India

Abstract: Polymeric membranes used as a barrier in guided tissue regeneration have undergone several modifications for improved structural, handling and biological properties. Biomaterial surface characteristics are critical in regulating cell function. Physicochemical signals from the substrate surfaces stimulate cell behaviour. This paper focuses on fabrication of biodegradable barrier membrane with hexagonal patterned surface for guided tissue regeneration. Hexagonal patterned surfaces were obtained during solvent casting of chitosan solution using a novel method. Obtained barrier membranes were analysed under stereo and electron microscopy and were assessed for their surface roughness. The hexagonal patterned surface barrier membranes had a significantly higher surface roughness (p < 0.001).

Keywords: barrier membrane; chitosan film; hexagonal; patterned surface; surface roughness; guided bone regeneration; GBR.

DOI: 10.1504/IJNBM.2018.094906

International Journal of Nano and Biomaterials, 2018 Vol.7 No.4, pp.275 - 281

Received: 01 May 2017
Accepted: 16 Jan 2018
Published online: 26 Sep 2018 *

Full-text access for editors Full-text access for subscribers Purchase this article Comment on this article