Title: Nanocomposites for luminescent tumour diagnostics and theranostics

Authors: A.V. Ivanov; I.P. Shilov; V.N. Nikiforov; N.P. Ivanovskaya; A.S. Gorshkova; V.D. Rumyantseva

Addresses: N.N. Blokhin Russian Cancer Research Center, Russian Ministry of Health, Moscow, 115478, Russia; State Scientific Center of Laser medicine FMBA, Moscow, 121165, Russia ' V.A. Kotel'nikov Institute of Radio Engineering and Electronics (Fryazino Branch), Russian Academy of Sciences, Moscow region, Fryazino, 141190, Russia ' Physics Department, M.V. Lomonosov Moscow State University, Moscow, 119991, Russia ' V.A. Kotel'nikov Institute of Radio Engineering and Electronics (Fryazino Branch), Russian Academy of Sciences, Moscow region, Fryazino, 141190, Russia; State Research Institute of Biological Engineering FMBA, Moscow, 125424, Russia ' Institute of Fine Chemical Technologies, Moscow Technological University, Moscow, 119571, Russia ' V.A. Kotel'nikov Institute of Radio Engineering and Electronics (Fryazino Branch), Russian Academy of Sciences, Moscow region, Fryazino, 141190, Russia; Institute of Fine Chemical Technologies, Moscow Technological University, Moscow, 119571, Russia

Abstract: This paper describes the synthesis method and the spectral-luminescent properties of nanoparticles containing the ytterbium complex of protoporphyrin IX dimethyl ether in Lexan-based polymer matrix which are promising for use in tumours diagnostics. For theranostics purposes, the synthesis of multifunctional nanoparticles containing iron oxide core and Lexan-polymer shell, including ytterbium porphyrin complexes (YPC), was carried out. The iron oxide nanoparticles are responsible for carrying out the local hyperthermia procedure when exposed to a high-frequency magnetic field.

Keywords: luminescent diagnostics; YPC; ytterbium porphyrin complexes; Lexan; iron oxide nanoparticles; theranostics.

DOI: 10.1504/IJNT.2018.094788

International Journal of Nanotechnology, 2018 Vol.15 No.4/5, pp.311 - 323

Received: 08 May 2021
Accepted: 12 May 2021

Published online: 10 Sep 2018 *

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