Open Access Article

Title: An approach to identify, prioritise and provide regulatory follow-up actions for new or emerging risks of chemicals for workers, consumers and the environment

Authors: Lya Guadalupe Soeteman-Hernández; Elbert Alex Hogendoorn; Joost Bakker; Fleur Antoinette Van Broekhuizen; Nicole Gertrudis Maria Palmen; Yuri Bruinen De Bruin; Myrna Kooi; Dick Theodorus Hubertus Maria Sijm; Theodoor Paul Traas

Addresses: Centre for Safety of Substances and Products, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, Netherlands ' Deceased; formerly of: Centre for Safety of Substances and Products, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, Netherlands ' Centre for Safety of Substances and Products, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, Netherlands ' Centre for Safety of Substances and Products, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, Netherlands ' Centre for Safety of Substances and Products, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, Netherlands ' Knowledge Management, European Commission Joint Research Centre, JRC Directorate E-Space, Security and Migration, Unit E.7 – Knowledge Management, Via E. Fermi 2749, TP 450, I-21027 Ispra, VA, Italy ' Formerly of: Centre for Safety of Substances and Products, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, Netherlands ' Office of Risk Assessment and Research, The Netherlands Food and Consumer Product Safety Authority, Catharijnesingel 59, 3511 GG Utrecht, Netherlands ' Centre for Sustainability, Environment and Health, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, the Netherlands

Abstract: This paper illustrates a comprehensive and systematic approach for the identification of new or emerging risks of chemicals (NERCs) for workers, consumers and the environment. The methodology illustrated here is composed of three steps: 1) signal identification; 2) signal evaluation and prioritisation and when necessary; 3) assessing follow-up actions for further risk management measures. During signal identification, new information with regard to adverse effects induced by the potential NERC is gathered using various information sources. Based on collected additional information, the causality between chemical exposure and the adverse effect is evaluated and prioritised. Finally, for those NERCs where there is sufficient proof of the causality with an adverse effect or the need for action, an analysis of possible appropriate regulatory risk management options is made. With this approach, NERCs can be efficiently identified with timely recommendations of follow-up steps, to reduce or eliminate the risk of the substance.

Keywords: exposure; prioritisation; evaluation; expert group; new or emerging risks of chemicals; NERCs; new risks; emerging risks; workers; consumers; environment; identification.

DOI: 10.1504/IJRAM.2018.093763

International Journal of Risk Assessment and Management, 2018 Vol.21 No.3, pp.248 - 269

Available online: 03 Aug 2018 *