Title: A comprehensive review on thin film-based nano-biosensor for uric acid determination: arthritis diagnosis

Authors: Panchatchram Parthasarathy; S. Vivekanandan

Addresses: School of Electrical Engineering, VIT University, Vellore, Tamilnadu, India ' School of Electrical Engineering, VIT University, Vellore, Tamilnadu, India

Abstract: This article aims to provide a survey on the development of thin film-based nano-biosensor over the decade, which includes sensing principles, electrode types and various thin film matrices. The theoretical and experimental results suggest that the thin film-based sensor are suitable for highly sensitive detection of low concentration bio molecules and can be used for early diagnosis and screening of arthritis, kidney diseases and other cardiovascular diseases. This review concludes that enzyme immobilisation and surface functionalisation methods were used to increase sensitivity of the biosensor and new combination of polymer nano-composites with metal oxide thin films results in increased efficiency due to its high biocompatibility.

Keywords: uric acid; immobilisation; enzymes; biocompatibility; thin films; nanomaterials.

DOI: 10.1504/WRSTSD.2018.092824

World Review of Science, Technology and Sustainable Development, 2018 Vol.14 No.1, pp.52 - 71

Received: 27 Sep 2017
Accepted: 16 Nov 2017

Published online: 18 Jun 2018 *

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