Title: Recent advances in the development of micropumps, microvalves and micromixers and the integration of carbon electrodes on centrifugal microfluidic platforms

Authors: Mohammad Mahdi Aeinehvand; Fatimah Ibrahim; Wisam Al-Faqheri; Karunan Joseph; Marc J. Madou

Addresses: Faculty of Engineering, Department of Biomedical Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia; Centre for Innovation in Medical Engineering (CIME), Faculty of Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia ' Faculty of Engineering, Department of Biomedical Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia; Centre for Innovation in Medical Engineering (CIME), Faculty of Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia ' Faculty of Engineering, Department of Biomedical Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia; Centre for Innovation in Medical Engineering (CIME), Faculty of Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia ' Faculty of Engineering, Department of Biomedical Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia; Centre for Innovation in Medical Engineering (CIME), Faculty of Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia ' Faculty of Engineering, Department of Biomedical Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia; Centre for Innovation in Medical Engineering (CIME), Faculty of Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia; Department of Biomedical Engineering, University of California, Irvine, 92697, USA; Department of Mechanical and Aerospace Engineering, University of California, Irvine, 92697, USA

Abstract: Centrifugal microfluidics is a field that has attracted many researchers over the last two decades and its application to biomedical analysis has been investigated intensively. This review paper presents recently developed innovative micropumps, microvalves and micromixers on microfluidic CDs that enabled the automation and integration of sequential bioanalytical assays. We also introduce and compare recent innovations in sensing and detection approaches in centrifugal microfluidic platforms. In this context, we propose the integration of carbon interdigitated electrode arrays (C-IDEAs) biosensors and microballoon fluidic components for the future development of highly sensitive, inexpensive and low-power consuming point-of-care (POC) diagnostic devices. To enable power on the CDs for the C-IDEAs biosensors, we review different formats for transferring power to the spinning platforms.

Keywords: centrifugal microfluidics; microfluidic compact-disc; microballoon; carbon interdigitated electrode arrays biosensor; optical biosensor; redox amplification; point-of-care diagnostic device; spin-stand; electrochemical.

DOI: 10.1504/IJNT.2018.089559

International Journal of Nanotechnology, 2018 Vol.15 No.1/2/3, pp.53 - 68

Available online: 12 Jan 2018 *

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