Title: The study on the cell survival for bioartificial liver by using standardisation extracorporeal circulation method

Authors: Seonghwan Kim; Minwoo Cheon

Addresses: School of Medicine, Department of Surgery, Chosun University, Gwangju, 61452, Republic of Korea ' Department of Health Administration, Dongshin University, Naju, 528245, Republic of Korea

Abstract: This research is on the standardisation of perfusion to help increase the survival rate of hepatic insufficiency patients through the enhanced cell survival of artificial livers. Generally, artificial livers are used in the form of extracorporeal circulation with a mounted bioreactor. As artificial livers need to replace liver functions, to enhance the liver cell survival ratio in the bioreactor, the bioreactor performance needs to be improved. To this end, perfusion standardisation is required in the extracorporeal circulation and each circulation pumps should be interoperable. In this study looked at possible standardisation of perfusion methods capable of increasing liver cell survival rate in order to find out the optimal standardised bioreactor. As a result, perfusion 2 control was found to be essential in raising the cell survival ratio and perfusion 3 implementation enhanced the survival ratio.

Keywords: extracorporeal circulation; standardisation; plasma perfusion; artificial organ; cell survival; artificial; bioreactor.

DOI: 10.1504/IJAMC.2017.089336

International Journal of Advanced Media and Communication, 2017 Vol.7 No.3, pp.197 - 204

Received: 18 Mar 2015
Accepted: 08 Feb 2016
Published online: 19 Jan 2018 *

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