Title: Cyclic voltametric study of some alkyl substituted N-hydroxy-2,6-diarylpiperidin-4-one semicarbazone and the antibacterial studies of the products

Authors: J.B. Veeramalini; G. Baskar; N. Sheeja

Addresses: Department of Chemical Engineering, Sri Ram Engineering College, Tiruvallur – 602024, India ' Department of Applied Chemistry, Sri Venkateswara College of Engineering, Pennalur – 602117, India ' Department of Chemistry, St. Joseph College of Engineering, Pennalur – 602117, India

Abstract: A series of 3-ethyl-2,6-diarylpiperidin-4-one semicarbazone and 3,5-dimethyl-2,6-diarylpiperidin-4-one semicarbazone were synthesised. The semicarbazones were subjected to cyclic voltammetric analysis using glassy carbon electrode with variable scan rate. The method involves electron transfer without the use of oxidising or reducing agents. The study of cyclic voltammogram showed that all the compounds have undergone irreversible reduction. The peak potential values, the number of peaks formed during the anodic and cathodic scan and the different scan rate used have established irreversible reduction reaction. The reduction products were isolated and purified by column chromatography. The structure is proved by 1H and 13C NMR spectroscopy. Further five products were analysed for anti bacterial activity and the nitro substituted compound showed a high inhibition towards Salmonella typii among the eight bacterial cultures.

Keywords: piperidone semicarbazone; cyclic voltammetry; CV; ¹H and ¹³C NMR; anti bacterial activity.

DOI: 10.1504/IJMPT.2017.084954

International Journal of Materials and Product Technology, 2017 Vol.55 No.1/2/3, pp.93 - 112

Received: 29 Apr 2016
Accepted: 25 Nov 2016
Published online: 09 Jul 2017 *

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