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Title: Parametric and non parametric distribution analysis of AkT for cell survival/death

Authors: Shruti Jain

Addresses: Department of Electronics and Communication Engineering, Jaypee University of Information Technology, 173234 Solan, India

Abstract: AkT (protein kinase B) is a central signalling molecule in the phosphatidylinositol 3-kinase (PI3K) pathway that is frequently activated in human cancer. AkT promotes cell survival/death by activating or deactivating different proteins. In this paper a model was designed using parametric or non parametric distribution analysis. Anderson Darling adjustment values was calculated using maximum likelihood and least square estimators as parametric function in which normal, Kaplan Meier and Herd Johnson tests were done for different distribution functions for ten cominations of TNF/EGF and insulin. For non-parametric analysis: survival and hazard plots were plotted using Kaplan Meier estimator.

Keywords: protein kinase B; AkT; distribution functions; Kaplan Meier; Herd Johnson.

DOI: 10.1504/IJAISC.2017.10005159

International Journal of Artificial Intelligence and Soft Computing, 2017 Vol.6 No.1, pp.43 - 55

Received: 27 Dec 2015
Accepted: 28 Jun 2016

Published online: 21 May 2017 *

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