Authors: V.N. Nikiforov; A.V. Ivanov; N.A. Brusentsov; T.S. Gendler; V.Yu. Irkhin
Addresses: Physics Department, M.V. Lomonosov Moscow State University, Moscow, 119991, Russia ' N.N. Blokhin Russian Cancer Research Center, Russian Ministry of Health, Moscow, 115478, Russia ' N.N. Blokhin Russian Cancer Research Center, Russian Ministry of Health, Moscow, 115478, Russia ' United Institute of the Earth Physics, RAS, Moscow, 123810, Russia ' Institute of Metal Physics, RAS, Ekaterinburg, 620990, Russia
Abstract: The water-based magnetite Fe3O4, maghemite γ-Fe2O3, Gd-substituted ferrites Fe[GdxFe2−x]O4, Ni-Cu alloy particles suspensions and dextran-ferrite (DF) solutions were prepared for the magnetically controlled thermochemotherapy (MCT). The temperature elevation prepared nanoparticles in AC magnetic field (0.88 MHz, 7.3 kA/m, 0.15 kW) and their toxicity were characterised. The results are in a good agreement with physical and chemical properties observed by in vitro measurements. The moment and Curie temperature of magnetic nanoparticles are obtained. The corresponding models of magnetic structure for magnetite, maghemite and Gd-doped ferrites are discussed.
Keywords: nanotechnology; magnetite; maghemite; magnetic nanoparticles; magnetic properties; AC magnetic field; Gd-substituted ferrites; gadolinium; toxicity; hyperthermia; biological properties; magnetically controlled thermochemotherapy; MCT; iron oxides; nickel alloys; copper; cancer therapy.
International Journal of Nanotechnology, 2017 Vol.14 No.7/8, pp.646 - 653
Received: 08 May 2021
Accepted: 12 May 2021
Published online: 30 Mar 2017 *