Open Access Article

Title: Integrating emerging technologies into chemical safety assessment: progress since the 2012 report of the expert panel on the integrated testing of pesticides

Authors: Leonard Ritter; Sam Kacew; Daniel Krewski

Addresses: School of Environmental Sciences, University of Guelph, Room 2114, Bovey Building, Guelph, ON N1G 2W1, Canada ' McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ontario K1G 3Z7, Canada ' McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ontario K1G 3Z7, Canada; Risk Science International, Ottawa, Ontario, Canada

Abstract: Governments need to categorise tens of thousands of data-poor chemicals in order to better inform human health risk assessment. Pesticide active ingredients have contributed considerably to our understanding of the toxicological mechanisms; however, in order to move forward there is a pressing need for testing that is faster and less expensive based upon the chemical specific mode-of-action (MOA). Currently, a comprehensive set of these alternative methods does not yet exist, although the state of the science is rapidly evolving. The next two to ten years will see a global progression towards the use of integrated testing strategies (ITS) in decision-making for both data-rich and data-poor chemicals. Regulatory deployment of integrated approaches to testing and assessment (IATA) will depend upon the types of chemicals and the nature of the decision-making process by regulatory authorities. Regulators need to recognise that adoption of IATA strategies would require the engagement and approval of public stakeholders in order to alleviate concerns regarding potential adverse risks to human health and the environment. The new approach cannot be used to simply streamline processes or sacrifice human and environmental safety for social or economic benefits.

Keywords: pesticides; toxicity testing; integrated approaches to testing and assessment; IATA; integrated testing strategies; ITS; chemical safety assessment; pesticide testing; human health risks; health risk assessment; safe chemicals; decision making; public engagement; public stakeholders; environmental safety.

DOI: 10.1504/IJRAM.2017.082559

International Journal of Risk Assessment and Management, 2017 Vol.20 No.1/2/3, pp.46 - 58

Available online: 27 Feb 2017 *