Title: Silver nanoparticles composition for treatment of distemper in dogs

Authors: Nina Bogdanchikova; Roberto Vázquez-Muñoz; Alejandro Huerta-Saquero; Antonio Pena-Jasso; Gildardo Aguilar-Uzcanga; Paola L. Picos-Díaz; Alexey Pestryakov; Vasilii Burmistrov; Oxana Martynyuk; Roberto Luna-Vázquez-Gómez; Horacio Almanza

Addresses: Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Km. 107 Carretera Tijuana a Ensenada, C.P. 22860, Ensenada, Baja California, Mexico ' Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Km. 107 Carretera Tijuana a Ensenada, C.P. 22860, Ensenada, Baja California, Mexico ' Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Km. 107 Carretera Tijuana a Ensenada, C.P. 22860, Ensenada, Baja California, Mexico ' Hospital Veterinario, Blvd. Costero 1548, Fracc. Playa Ensenada, Ensenada, B.C., Mexico ' Centro Veterinario Aguzvet, Ruiz 1373, Ensenada Centro, Ensenada, C.P. 22800, B.C., Mexico ' Clínica Veterinaria Albéitar, Blvd. Popotla, Carr. Libre Tijuana-Ensenada 742, Col. Villa Corona del Mar, Rosarito, B.C., Mexico ' Department of Technology of Organic Substances and Polymer Materials, Tomsk Polytechnic University, Tomsk 634050, Russia ' Research and Production Center 'Vector-Vita' Ltd., Koltsovo, Novosibirsk, Russia ' Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Km. 107 Carretera Tijuana a Ensenada, C.P. 22860, Ensenada, Baja California, Mexico; Tomsk Polytechnic University, Tomsk 634050, Russia ' Universidad Autónoma de Baja California, Carr. Ensenada-Tijuana No. 3917, C.P. 22860, Ensenada, B.C., Mexico ' Universidad Autónoma de Baja California, Carr. Ensenada-Tijuana No. 3917, C.P. 22860, Ensenada, B.C., Mexico

Abstract: Canine distemper is caused by the canine distemper virus (CDV), a paramyxovirus of the genus Morbillivirus, with a worldwide distribution. Canine distemper is a multisystem disease, potentially fatal. Affected organisms may develop clinical or subclinical infections, among them respiratory, gastrointestinal and of the nervous system. In the present work, we use a veterinary pharmaceutical composition of silver nanoparticles (AgNPs) for the treatment of distemper in dogs with neurological and non-neurological symptoms. AgNPs treatment of animals with non-neurological distemper provides a very high rate of recovery without sequelae. However, in dogs with neurological symptoms, AgNPs treatment was not able to reverse the disease.

Keywords: AgNPs treatment; canine distemper virus; CDV; distemper virus; silver nanoparticles; distemper treatment; dogs; nanotechnology; neurological symptoms; non-neurological symptoms.

DOI: 10.1504/IJNT.2016.074536

International Journal of Nanotechnology, 2016 Vol.13 No.1/2/3, pp.227 - 237

Available online: 04 Feb 2016 *

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