Title: Improvement of osseointegration of Ti and Ti-alloys by hydrothermally prepared bioactive anatase coating

Authors: Nataša Drnovšek; Urška Dragin Jerman; Rok Romih; Miran Čeh; Matevž Gorenšek; Jozef Vleugels; Saša Novak

Addresses: Department for Nanostructured Materials, Jožef Stefan Institute, Jamova cesta 39, SI-1000 Ljubljana, Slovenia ' Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Vrazovtrg 2, SI-1000 Ljubljana, Slovenia ' Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Vrazovtrg 2, SI-1000 Ljubljana, Slovenia ' Department for Nanostructured Materials, Jožef Stefan Institute, Jamova cesta 39, SI-1000 Ljubljana, Slovenia ' Department of Orthopaedic Surgery Ljubljana, University Medical Centre Ljubljana, Zaloška 9, SI-1000 Ljubljana, Slovenia ' Department of Metallurgy and Materials Engineering (MTM), KU Leuven, 3001 Heverlee Leuven, Belgium ' Department for Nanostructured Materials, Jožef Stefan Institute, Jamova cesta 39, SI-1000 Ljubljana, Slovenia

Abstract: This paper reports on the in vivo behaviour of Ti6Al4V alloy substrates with or without a porous Ti layer that were coated with a thin layer of anatase TiO2 by a hydrothermal treatment. In vivo tests were performed on TiO2 coating with certain morphology, i.e. pinacoidal anatase, which was proven in our previous studies to have better bioactive characteristics then other anatase morphology. A pronounced effect of the hydrothermally prepared TiO2 coating was seen with the in vivo test where Ti6Al4V implants with a porous Ti layer on the surface were implanted in rabbit tibia for ten weeks. There was a large increase in the amount of mineralised bone within the porous Ti layer when the implant was coated with anatase TiO2.

Keywords: bone ingrowth; hydrothermal synthesis; osseointegration; TiO2 coatings; in vivo test; porous implants; Ti6Al4V; titanium alloys; bioactive anatase coatings; pinacoidal anatase; rabbit tibia; mineralised bone; titanium dioxide; titania.

DOI: 10.1504/IJNBM.2015.073147

International Journal of Nano and Biomaterials, 2015 Vol.6 No.1, pp.18 - 28

Available online: 20 Nov 2015 *

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