Title: Magnetic iron oxide nanoparticles: preparation and hyperthermia applications

Authors: Thanaa I. Shalaby; Yousef Selim Yousef; Mostafa M. Mohamed; Hisham A. Badawy; Doaa T. Gebreel

Addresses: Medical Biophysics Department, Medical Research Institute, Alexandria University, Egypt ' Medical Biophysics Department, Medical Research Institute, Alexandria University, Egypt ' Department of Medical Equipment Technology, Faculty of Allied Medical Science, University of Pharous, Alexandria, Egypt ' Radiology Department, Medical Research Institute, Alexandria University, Egypt ' Medical Biophysics Department, Medical Research Institute, Alexandria University, Egypt

Abstract: The magnetic hyperthermia is based on localised heating of tumour keeping the healthy cells out of harm. In the process, magnetic hyperthermia involves dispersing magnetic nanoparticles (MNPs) throughout the target tissue and then exposed to ultrasound and/or microwave energy to cause the particles to be heated up to the required temperature of about 45°C. Superparamagnetic nanoparticles were prepared through the co-precipitation method and characterised using TEM, SEM, X-ray diffractometer and Fourier transform-infrared (FTIR). Magnetic behaviour of nanoparticles was studied using vibrating-sample magnetometer (VSM). Through the treatment period, tumour volume was determined every other day. After treatment period, the dielectric properties of the treated tissues were determined. Tumour apoptosis was studied using transmission electron microscope. The results indicate that the magnetic fluid is a suitable mediator for cancer treatment using hyperthermia application with appropriate controlling the heating temperature ranges from 45 to 50°C using microwave and/or ultrasound energy.

Keywords: superparamagnetic nanoparticles; magnetic properties; magnetic fluid hyperthermia; co-precipitation; microwave energy; ultrasound energy; dielectric properties; magnetic iron oxide; nanotechnology; localised heating; tumours; magnetic hyperthermia; magnetic nanoparticles; tumour volume; tumour apoptosis; cancer treatment.

DOI: 10.1504/IJNP.2015.071745

International Journal of Nanoparticles, 2015 Vol.8 No.2, pp.115 - 131

Available online: 17 Sep 2015 *

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